FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103291816> ?p ?o ?g. }

• W2103291816 endingPage "564" @default.
• W2103291816 startingPage "557" @default.
• W2103291816 abstract "A wide range of human pathologies, including neurodegenerative diseases and other forms of amyloidosis, are associated with the formation of insoluble fibrillar protein aggregates known as amyloids. To gain insights into this process analytical methods are needed, which give quantitative data on the molecular events that are taking place. The dye Thioflavin T (ThT) is widely used for the spectroscopic determination of amyloid fibril formation. Different binding affinities to amyloids at neutral and acidic pH and the frequently observed poor binding at acidic pH are problematic in the use of the cationic ThT. The uncharged fluorescence probe [[5′-(4-hydroxyphenyl)[2,2′-bithiophen]-5-yl]methylene]-propanedinitrile (NIAD-4) has been recently designed by Swager and coworkers, in order to eliminate some of the limitations of ThT. Here we have used this novel dye for in vitro monitoring of the amyloid formation processes of de novo designed model peptides. Amyloid structures were successfully detected by NIAD-4 at neutral as well as acidic pH and no significant fluorescence was detectable in the presence of α-helical fibres. Thus, NIAD-4 proved to be a valuable alternative to ThT for spectroscopic studies on amyloid structures over a broad pH range." @default.
• W2103291816 created "2016-06-24" @default.
• W2103291816 creator A5059077354 @default.
• W2103291816 creator A5063060689 @default.
• W2103291816 creator A5090358850 @default.
• W2103291816 date "2012-01-01" @default.
• W2103291816 modified "2023-09-27" @default.
• W2103291816 title "Specific in situ discrimination of amyloid fibrilsversus α-helical fibres by the fluorophore NIAD-4" @default.
• W2103291816 cites W1560197628 @default.
• W2103291816 cites W1584073114 @default.
• W2103291816 cites W1588296570 @default.
• W2103291816 cites W1856532105 @default.
• W2103291816 cites W1966618450 @default.
• W2103291816 cites W1971094393 @default.
• W2103291816 cites W1972011321 @default.
• W2103291816 cites W1972850054 @default.
• W2103291816 cites W1974203666 @default.
• W2103291816 cites W1982941258 @default.
• W2103291816 cites W1984729685 @default.
• W2103291816 cites W2005212584 @default.
• W2103291816 cites W2006510253 @default.
• W2103291816 cites W2007337268 @default.
• W2103291816 cites W2009604591 @default.
• W2103291816 cites W2010462701 @default.
• W2103291816 cites W2013382725 @default.
• W2103291816 cites W2016162029 @default.
• W2103291816 cites W2018562413 @default.
• W2103291816 cites W2021491712 @default.
• W2103291816 cites W2024424098 @default.
• W2103291816 cites W2028082955 @default.
• W2103291816 cites W2038399240 @default.
• W2103291816 cites W2038913139 @default.
• W2103291816 cites W2040562441 @default.
• W2103291816 cites W2041252400 @default.
• W2103291816 cites W2044165215 @default.
• W2103291816 cites W2044623253 @default.
• W2103291816 cites W2053041274 @default.
• W2103291816 cites W2057709942 @default.
• W2103291816 cites W2058469726 @default.
• W2103291816 cites W2060215277 @default.
• W2103291816 cites W2061627162 @default.
• W2103291816 cites W2061635955 @default.
• W2103291816 cites W2062924950 @default.
• W2103291816 cites W2066767743 @default.
• W2103291816 cites W2068157315 @default.
• W2103291816 cites W2068229278 @default.
• W2103291816 cites W2073213467 @default.
• W2103291816 cites W2078024350 @default.
• W2103291816 cites W2082501707 @default.
• W2103291816 cites W2096601751 @default.
• W2103291816 cites W2097965815 @default.
• W2103291816 cites W2102974517 @default.
• W2103291816 cites W2112559570 @default.
• W2103291816 cites W2115537581 @default.
• W2103291816 cites W2121963977 @default.
• W2103291816 cites W2123021161 @default.
• W2103291816 cites W2129998022 @default.
• W2103291816 cites W2133883490 @default.
• W2103291816 cites W2134802476 @default.
• W2103291816 cites W2136355739 @default.
• W2103291816 cites W2137496015 @default.
• W2103291816 cites W2142337553 @default.
• W2103291816 cites W2144729056 @default.
• W2103291816 cites W2148749993 @default.
• W2103291816 cites W2151720205 @default.
• W2103291816 cites W2154255598 @default.
• W2103291816 cites W2161710266 @default.
• W2103291816 cites W2165186407 @default.
• W2103291816 cites W2166745505 @default.
• W2103291816 cites W2168898515 @default.
• W2103291816 cites W2169727673 @default.
• W2103291816 cites W2172219847 @default.
• W2103291816 cites W2332581925 @default.
• W2103291816 doi "https://doi.org/10.1039/c1mb05370a" @default.
• W2103291816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22116468" @default.
• W2103291816 hasPublicationYear "2012" @default.
• W2103291816 type Work @default.
• W2103291816 sameAs 2103291816 @default.
• W2103291816 citedByCount "16" @default.
• W2103291816 countsByYear W21032918162012 @default.
• W2103291816 countsByYear W21032918162013 @default.
• W2103291816 countsByYear W21032918162014 @default.
• W2103291816 countsByYear W21032918162015 @default.
• W2103291816 countsByYear W21032918162016 @default.
• W2103291816 countsByYear W21032918162018 @default.
• W2103291816 countsByYear W21032918162019 @default.
• W2103291816 countsByYear W21032918162020 @default.
• W2103291816 countsByYear W21032918162021 @default.
• W2103291816 countsByYear W21032918162022 @default.
• W2103291816 crossrefType "journal-article" @default.
• W2103291816 hasAuthorship W2103291816A5059077354 @default.
• W2103291816 hasAuthorship W2103291816A5063060689 @default.
• W2103291816 hasAuthorship W2103291816A5090358850 @default.
• W2103291816 hasConcept C121332964 @default.
• W2103291816 hasConcept C12554922 @default.
• W2103291816 hasConcept C142724271 @default.
• W2103291816 hasConcept C179104552 @default.
• W2103291816 hasConcept C185592680 @default.

• next