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- W2103292250 abstract "SummaryThe mechanism by which gold acts in rheumatoid arthritis is not properly understood. It is only known that the gold compounds block the SH groups of glutathione, cysteine and perhaps other sulfhydryl compounds in the body and partly inhibit normal oxireduction processes in the cells.Thus also the mechanism by which the toxic reactions of gold therapy are produced is obscure. It must be some form of idiosyncrasy. The beneficial effect of BAL in such cases might be explained by its ability to break down the gold protein bond through competing effectively with the sulfhydryl groups of various tissue proteins for the gold. If BAL is given early and in adequate doses, all the reactions disappear.To use adrenocorticoids as the only therapeutic agent in gold reactions involves the risk of controlling the symptoms without due regard to the fact that the causing agent is still remaining. In many cases chronic pathologic skin changes persist. Auridosis will be one of its sequels." @default.
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- W2103292250 date "1959-12-01" @default.
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- W2103292250 title "Value and Complications of Gold Therapy in Rheumatoid Arthritis" @default.
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- W2103292250 doi "https://doi.org/10.3109/rhe1.1959.5.issue-1-4.08" @default.
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