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• W2103292506 endingPage "1382" @default.
• W2103292506 startingPage "1374" @default.
• W2103292506 abstract "Proopiomelanocortin (POMC) is a precursor of adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), and endorphin (END). We have characterized POMC systems in barfin flounder. The results revealed unique aspects of POMC systems. Notable features in terms of pituitary functions are the occurrence of three functional POMC genes, the mutation of an essential sequence in the β-END in one of the genes, occurrence of α-MSH in addition to ACTH in the pars distalis of the pituitary, and expression of the three genes in a single cell. While MSHs stimulate pigment dispersion, expression of the POMC gene and plasma levels of MSH do not always respond to background color changes between black and white. The functions of MSHs in skin pigmentation are very unique, because acetylation at the N-terminal of α-MSH inhibits its pigment dispersing activity. This is in contrast to results from other teleosts and amphibians, in which acetylation increases the activity. In the skin, the POMC gene is expressed in the non-chromatophoric dermal cells, indicating that MSH produced in the skin de novo has a paracrine function. The detection of MSH peptides in skin extracts seems to show that the control of skin pigmentation by MSHs is twofold—endocrine control by the pituitary, and paracrine control by the skin itself. Thus, fish provide an interesting model to help understand the structural and functional diversity of POMC systems. In this review, we provide an overview of our recent studies on the characterization of molecules and biological significance of POMC systems in barfin flounder." @default.
• W2103292506 created "2016-06-24" @default.
• W2103292506 creator A5039320286 @default.
• W2103292506 creator A5042635434 @default.
• W2103292506 creator A5065972231 @default.
• W2103292506 creator A5077045599 @default.
• W2103292506 date "2009-07-01" @default.
• W2103292506 modified "2023-09-27" @default.
• W2103292506 title "Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder" @default.
• W2103292506 cites W1681652601 @default.
• W2103292506 cites W1964387150 @default.
• W2103292506 cites W1964415516 @default.
• W2103292506 cites W1967426812 @default.
• W2103292506 cites W1972563768 @default.
• W2103292506 cites W1975404084 @default.
• W2103292506 cites W1975727321 @default.
• W2103292506 cites W1980829334 @default.
• W2103292506 cites W1982287277 @default.
• W2103292506 cites W1983244030 @default.
• W2103292506 cites W1984622423 @default.
• W2103292506 cites W1985156922 @default.
• W2103292506 cites W1985737359 @default.
• W2103292506 cites W1986784382 @default.
• W2103292506 cites W1989768619 @default.
• W2103292506 cites W1989993782 @default.
• W2103292506 cites W1993056869 @default.
• W2103292506 cites W1997112551 @default.
• W2103292506 cites W2000260719 @default.
• W2103292506 cites W2000448219 @default.
• W2103292506 cites W2002539447 @default.
• W2103292506 cites W2005123729 @default.
• W2103292506 cites W2005962494 @default.
• W2103292506 cites W2006319400 @default.
• W2103292506 cites W2007919092 @default.
• W2103292506 cites W2010142606 @default.
• W2103292506 cites W2013551319 @default.
• W2103292506 cites W2016283722 @default.
• W2103292506 cites W2016877878 @default.
• W2103292506 cites W2017934739 @default.
• W2103292506 cites W2020046922 @default.
• W2103292506 cites W2022502566 @default.
• W2103292506 cites W2024218703 @default.
• W2103292506 cites W2024492251 @default.
• W2103292506 cites W2024596477 @default.
• W2103292506 cites W2027092872 @default.
• W2103292506 cites W2027778502 @default.
• W2103292506 cites W2031587745 @default.
• W2103292506 cites W2035478782 @default.
• W2103292506 cites W2036510719 @default.
• W2103292506 cites W2038510532 @default.
• W2103292506 cites W2039495394 @default.
• W2103292506 cites W2039980885 @default.
• W2103292506 cites W2041531639 @default.
• W2103292506 cites W2042111410 @default.
• W2103292506 cites W2046281192 @default.
• W2103292506 cites W2048700608 @default.
• W2103292506 cites W2051889610 @default.
• W2103292506 cites W2051988666 @default.
• W2103292506 cites W2052788650 @default.
• W2103292506 cites W2057299801 @default.
• W2103292506 cites W2058549776 @default.
• W2103292506 cites W2059940682 @default.
• W2103292506 cites W2060485874 @default.
• W2103292506 cites W2063763885 @default.
• W2103292506 cites W2064547672 @default.
• W2103292506 cites W2064924810 @default.
• W2103292506 cites W2065389660 @default.
• W2103292506 cites W2065874893 @default.
• W2103292506 cites W2066431237 @default.
• W2103292506 cites W2068993393 @default.
• W2103292506 cites W2069485543 @default.
• W2103292506 cites W2074930310 @default.
• W2103292506 cites W2075803936 @default.
• W2103292506 cites W2076708673 @default.
• W2103292506 cites W2079497611 @default.
• W2103292506 cites W2081517676 @default.
• W2103292506 cites W2081792585 @default.
• W2103292506 cites W2086552980 @default.
• W2103292506 cites W2090469958 @default.
• W2103292506 cites W2096383275 @default.
• W2103292506 cites W2097211923 @default.
• W2103292506 cites W2115622142 @default.
• W2103292506 cites W2128822914 @default.
• W2103292506 cites W2134072928 @default.
• W2103292506 cites W2136061619 @default.
• W2103292506 cites W2136226486 @default.
• W2103292506 cites W2141433061 @default.
• W2103292506 cites W2142806913 @default.
• W2103292506 cites W2146743950 @default.
• W2103292506 cites W2155095345 @default.
• W2103292506 cites W2161224871 @default.
• W2103292506 cites W2171836809 @default.
• W2103292506 cites W2172019568 @default.
• W2103292506 cites W4231107320 @default.
• W2103292506 cites W4240255801 @default.
• W2103292506 cites W4256101048 @default.
• W2103292506 doi "https://doi.org/10.1016/j.peptides.2009.04.014" @default.
• W2103292506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19409435" @default.

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