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- W2103293789 abstract "Euphorbia coerulescens (Fam. Euphorbiaceae) or Sweetnoors is indigenous to South Africa, where it is used as an animal feedstuff. Several more toxic species including E. franckiana, E. ledienii and E. cooperi, are indigenous to the same area. The relative toxicities of these latices were assessed by a mouse ear irritancy test. E. coerulescens, E. franckiana and E. ledienii were of low toxicity, whilst E. cooperi was more potent. Six esters isolated from the latex of E. coerulescens produced inflammation of mice ears. Two esters were identified as diesters of 12-deoxyphorbol and 3 were monoesters of the same diterpene. The sixth compound was a triester of phorbol. Structures were elucidated by infra-red, ultra violet and nuclear magnetic resonance spectroscopy, mass-spectrometry and circular dichroism, together with selective hydrolysis and partial synthesis. Comparisons of toxicity of the pure esters after both 4 and 24 hr suggested that compounds with a free C-20 hydroxyl group and a trans A B ring fusion were more potent and their effects longer lasting. The low toxicity of Sweetnoors latex is due to low yields of esters and to the fact that C-20 acylated diterpenes predominated in the mixture." @default.
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- W2103293789 date "1975-02-01" @default.
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- W2103293789 title "Isolation of phorbol from Euphorbia franckiana" @default.
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- W2103293789 doi "https://doi.org/10.1016/0031-9422(75)85139-9" @default.
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