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• W2103295152 abstract "BEFORE discussing the diathermic method of producing therapeutic fever, it will be necessary to consider in a general way some of the facts pertaining to fever itself. Fever is a reaction within the body characterized by certain symptoms and signs, the most outstanding of which are an elevation of the general body temperature and an increased metabolic rate. These reactions represent an imbalance of those physical and chemical mechanisms which maintain the normal temperature of the body in health. The physical operates through the sympathetic nervous system, controlling heat dissipation from the body by its vasomotor effect on the peripheral arterioles. The chemical increases or decreases the amount of heat production through metabolic processes. Beneficial Effects of Fever Within the last decade, medical science has recognized that pyrexia is a defense reaction which protects the body against injurious agents by facilitating the production, and hastening the action, of substances or specific antibodies found in the body that combat bacteria and their toxic products. It is apparent that other factors are also at work in induced pyrexia. Sustained high temperature causes peripheral vasodilatation, and has a direct thermic effect on the causative infectious organisms. Rolly and Meltzer (1), as well as others, have found that animals kept at a high termperature in a thermostat room develop a much more effective defense against intoxications and infections than those left outside at ordinary temperatures. By injecting small doses of bacteria or toxins as they occur in diseases, the heated animals show many advantages over the controls by living longer; many of them survive doses that inevitably kill the control animals. It is true that infectious diseases, accompanied by rise of temperature, are self-limiting. On the other hand, it is equally evident that afebrile infections are not self-limiting. Syphilis, gonorrheal infections, and the arthritides are included in this category. Efforts to control these with artificial fever produced by diathermy have met with noteworthy success. Repeated experiments by Bessemans (2) have proved that temperatures of 40° C. for two hours, or 42° C. for one hour, have an intense destructive action upon emulsions of active syphilitic virus, prepared from specific lesions of animals or man. If the syphilitic testicles of rabbits are treated with heat in the form of a continuous bath at these temperatures, the orchitic primary manifestations of syphilis are cured with certainty, without apparent danger to the organ or the general organism. The treponema become immobile and disappear after 24 hours or more, and the tissues of the organ rapidly resume their normal microscopic aspect." @default.
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• W2103295152 date "1933-06-01" @default.
• W2103295152 modified "2023-09-26" @default.
• W2103295152 title "Therapeutic Fever Produced by Diathermy" @default.
• W2103295152 doi "https://doi.org/10.1148/20.6.449" @default.
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