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- W2103305083 abstract "While clinical trials with fibrates have not always shown remarkable benefits for the incidence of cardiovascular disease (CVD) and mortality in particular, not only pure lipid (triglyceride)-lowering effects of fibrates but also non-lipid/pleiotropic effects (such as antifibrinolytic/antithrombotic and peroxisome proliferator activated receptor-mediated properties) on atherogenesis are considered [ 1 Remick J. Weintraub H. Setton R. et al. Fibrate therapy: an update. Cardiol Rev. 2008; 16: 129-141 Crossref PubMed Scopus (69) Google Scholar , 2 Elkeles RS Diamond JR Poulter C et al. Cardiovascular outcomes in type 2 diabetes. A double-blind placebo-controlled study of bezafibrate: the St. Mary's, Ealing, Northwick Park Diabetes Cardiovascular Disease Prevention (SENDCAP) Study. Diabetes Care. 1998; 21: 641-648 Crossref PubMed Scopus (258) Google Scholar , 3 Milionis H.J. Elisaf M.S. Mikhailidis D.P. Treatment of dyslipidaemias in patients with established vascular disease: a revival of the fibrates. Curr Med Res Opin. 2000; 16: 21-32 PubMed Google Scholar ]. The roles of fibrates on the oxidization of low-density lipoprotein (LDL) may be an attractive example. While bezafibrate can reportedly enhance oxidation in blood [ [4] de Man F.H. Jonkers I.J. Schwedhelm E. et al. Normal oxidative stress and enhanced lipoprotein resistance to in vitro oxidation in hypertriglyceridemia: effects of bezafibrate therapy. Arterioscler Thromb Vasc Biol. 2000; 20: 2434-2440 Crossref PubMed Scopus (17) Google Scholar ], this agent can decrease LDL-oxidizability [ 5 Hoffman R. Brook G.J. Aviram M. Hypolipidemic drugs reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies. Atherosclerosis. 1992; 93: 105-113 Abstract Full Text PDF PubMed Scopus (102) Google Scholar , 6 Zambrana J.L. López-Miranda J. Blanco A. et al. Bezafibrate and lovastatin decrease the oxidizability of low-density lipoproteins in heart transplant recipients with hyperlidemia. J Heart Lung Transplant. 1998; 17: 1213-1219 PubMed Google Scholar ]; however, there is little information available concerning ‘circulating’ oxidized-LDL. Serum amyloid A (SAA)–LDL complex is a new oxidized-LDL marker formed under hyperoxidative environments [ [7] Kotani K. Satoh N. Kato Y. et al. A novel oxidized low-density lipoprotein marker, serum amyloid A–LDL, is associated with obesity and the metabolic syndrome. Atherosclerosis. 2009; 204: 526-531 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar ]. This study investigated preliminarily the lipid-independent association between bezafibrate and SAA–LDL among type 2 diabetic patients with hypertriglyceridemia." @default.
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- W2103305083 date "2010-04-01" @default.
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- W2103305083 title "Bezafibrate and serum amyloid A–low-density lipoprotein complex in patients with type 2 diabetes mellitus and hypertriglyceridemia" @default.
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- W2103305083 doi "https://doi.org/10.1016/j.ejim.2009.12.007" @default.
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