FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103306578> ?p ?o ?g. }

• W2103306578 endingPage "1421" @default.
• W2103306578 startingPage "1417" @default.
• W2103306578 abstract "Objectives. To study the relationship between clinical manifestations in systemic lupus erythematosus (SLE) with polymorphisms in suggested susceptibility genes encoding FcγRIIa, FcγRIIIa, FcγRIIIb, CRP and IL-1Ra. Methods. Genetic polymorphisms were analysed in 323 unrelated SLE patients and 200 healthy blood donors. The genotype frequencies were compared between clinical subsets of SLE patients, as well as with healthy controls. Clinical manifestations included the ACR classification criteria. Nephritis was further classified according to WHO class on renal biopsy. Results. Presence of a CRP4 A-allele was associated with SLE nephritis (P < 0.01) and inversely correlated with arthritis (P < 0.01), when comparing within the SLE group. The FcγRIIIa F/F genotype was also associated with nephritis (WHO class III and IV, P = 0.04 for the SLE group) and in combination with the CRP4 A-allele a stronger association was noted (P < 0.001). Furthermore, the FcγRIIIb NA2/NA2 genotype was associated with butterfly rash (P < 0.01). An association was found between seizures and the presence of both the FcγRIIa R/R and the FcγRIIIa F/F genotypes (P < 0.01) and an inverse correlation between serositis and the CRP4 A-allele when present together with the IL-1Ra 2-allele (P = 0.01). Furthermore, a combination of the FcγRIIa R/R genotype and CRP4 A-allele was associated with lymphopenia (P = 0.02) and a similar result was found for the combination of FcγRIIIa F/F and FcγRIIIb NA2/NA2 (P = 0.04). Conclusions. Polymorphic variants of the CRP and Fcγ-receptor genes are associated with the clinical phenotype in SLE. Our findings suggest an immune complex-mediated pathogenesis in nephritis and seizures, while development of arthritis may depend on other pathogenetic pathways." @default.
• W2103306578 created "2016-06-24" @default.
• W2103306578 creator A5002914719 @default.
• W2103306578 creator A5011002229 @default.
• W2103306578 creator A5016488933 @default.
• W2103306578 creator A5016564929 @default.
• W2103306578 creator A5017309664 @default.
• W2103306578 creator A5018447862 @default.
• W2103306578 creator A5028042265 @default.
• W2103306578 creator A5037276492 @default.
• W2103306578 creator A5053954343 @default.
• W2103306578 date "2007-06-27" @default.
• W2103306578 modified "2023-10-16" @default.
• W2103306578 title "Association between SLE nephritis and polymorphic variants of the CRP and Fc RIIIa genes" @default.
• W2103306578 cites W1481391572 @default.
• W2103306578 cites W1514195725 @default.
• W2103306578 cites W1581067810 @default.
• W2103306578 cites W1597614503 @default.
• W2103306578 cites W1605213317 @default.
• W2103306578 cites W1745556869 @default.
• W2103306578 cites W1817930542 @default.
• W2103306578 cites W1863751168 @default.
• W2103306578 cites W1932537843 @default.
• W2103306578 cites W1970265735 @default.
• W2103306578 cites W1970963947 @default.
• W2103306578 cites W1986160938 @default.
• W2103306578 cites W1989236531 @default.
• W2103306578 cites W1995698027 @default.
• W2103306578 cites W2002621113 @default.
• W2103306578 cites W2004913283 @default.
• W2103306578 cites W2005313701 @default.
• W2103306578 cites W2005402133 @default.
• W2103306578 cites W2011470349 @default.
• W2103306578 cites W2016086466 @default.
• W2103306578 cites W2031114802 @default.
• W2103306578 cites W2035553541 @default.
• W2103306578 cites W2035996425 @default.
• W2103306578 cites W2039537005 @default.
• W2103306578 cites W2040840074 @default.
• W2103306578 cites W2049266087 @default.
• W2103306578 cites W2064162749 @default.
• W2103306578 cites W2065219238 @default.
• W2103306578 cites W2067378754 @default.
• W2103306578 cites W2071637285 @default.
• W2103306578 cites W2080843292 @default.
• W2103306578 cites W2085406842 @default.
• W2103306578 cites W2086027166 @default.
• W2103306578 cites W2091987708 @default.
• W2103306578 cites W2094820202 @default.
• W2103306578 cites W2097325034 @default.
• W2103306578 cites W2098761249 @default.
• W2103306578 cites W2106669554 @default.
• W2103306578 cites W2108905161 @default.
• W2103306578 cites W2118076456 @default.
• W2103306578 cites W2118094114 @default.
• W2103306578 cites W2126999602 @default.
• W2103306578 cites W2137640241 @default.
• W2103306578 cites W2146203649 @default.
• W2103306578 cites W2148045758 @default.
• W2103306578 cites W2148344341 @default.
• W2103306578 cites W2153384132 @default.
• W2103306578 cites W2181317190 @default.
• W2103306578 cites W2606510613 @default.
• W2103306578 cites W1973974259 @default.
• W2103306578 cites W2039977529 @default.
• W2103306578 doi "https://doi.org/10.1093/rheumatology/kem167" @default.
• W2103306578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17596285" @default.
• W2103306578 hasPublicationYear "2007" @default.
• W2103306578 type Work @default.
• W2103306578 sameAs 2103306578 @default.
• W2103306578 citedByCount "57" @default.
• W2103306578 countsByYear W21033065782012 @default.
• W2103306578 countsByYear W21033065782013 @default.
• W2103306578 countsByYear W21033065782014 @default.
• W2103306578 countsByYear W21033065782015 @default.
• W2103306578 countsByYear W21033065782016 @default.
• W2103306578 countsByYear W21033065782017 @default.
• W2103306578 countsByYear W21033065782018 @default.
• W2103306578 countsByYear W21033065782022 @default.
• W2103306578 countsByYear W21033065782023 @default.
• W2103306578 crossrefType "journal-article" @default.
• W2103306578 hasAuthorship W2103306578A5002914719 @default.
• W2103306578 hasAuthorship W2103306578A5011002229 @default.
• W2103306578 hasAuthorship W2103306578A5016488933 @default.
• W2103306578 hasAuthorship W2103306578A5016564929 @default.
• W2103306578 hasAuthorship W2103306578A5017309664 @default.
• W2103306578 hasAuthorship W2103306578A5018447862 @default.
• W2103306578 hasAuthorship W2103306578A5028042265 @default.
• W2103306578 hasAuthorship W2103306578A5037276492 @default.
• W2103306578 hasAuthorship W2103306578A5053954343 @default.
• W2103306578 hasBestOaLocation W21033065781 @default.
• W2103306578 hasConcept C104317684 @default.
• W2103306578 hasConcept C126322002 @default.
• W2103306578 hasConcept C135763542 @default.
• W2103306578 hasConcept C149443304 @default.
• W2103306578 hasConcept C159654299 @default.
• W2103306578 hasConcept C163764329 @default.
• W2103306578 hasConcept C180754005 @default.

• next