Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103307139> ?p ?o ?g. }
- W2103307139 endingPage "1486" @default.
- W2103307139 startingPage "1479" @default.
- W2103307139 abstract "PIM kinases are a family of serine/threonine kinases composed of three different isoforms (PIM1, PIM 2 and PIM 3) that are highly homologous. Their expression is mediated by the JAK/STAT signalling pathway, providing survival and cell cycle transition signals. PIM kinases are heavily targeted for anticancer drug discovery. However, very little is known about the relative contribution of the different isoforms to the tumourigenesis process in vivo, and how their individual inhibition might affect tumour growth. Taking advantage of genetically modified mice, we explored whether the inhibition of specific isoforms is required to prevent sarcomas induced by 3-methylcholanthrene carcinogenic treatment. We found that absence of Pim2 and Pim3 greatly reduced sarcoma growth to a similar extent to the absence of all three isoforms. This model of sarcoma generally produces bone invasion by the tumour cells. Lack of Pim2 and Pim3 reduced tumour-induced bone invasion by 70%, which is comparable with the reduction of tumour-induced bone invasion in the absence of all three isoforms. Similar results were obtained in mouse embryonic fibroblasts (MEFs) derived from these knockout (KO) mice, where double Pim2/3 KO MEFs already showed reduced proliferation and were resistant to oncogenic transformation by the RAS oncogene. Our data also suggest an important role of Gsk3β phosphorylation in the process of tumourigenesis." @default.
- W2103307139 created "2016-06-24" @default.
- W2103307139 creator A5017542401 @default.
- W2103307139 creator A5029217625 @default.
- W2103307139 creator A5038929958 @default.
- W2103307139 creator A5051516116 @default.
- W2103307139 creator A5056464877 @default.
- W2103307139 creator A5059066999 @default.
- W2103307139 creator A5063985660 @default.
- W2103307139 creator A5079853904 @default.
- W2103307139 date "2012-05-22" @default.
- W2103307139 modified "2023-10-07" @default.
- W2103307139 title "The essential role of PIM kinases in sarcoma growth and bone invasion" @default.
- W2103307139 cites W1517422587 @default.
- W2103307139 cites W1534399129 @default.
- W2103307139 cites W1592498390 @default.
- W2103307139 cites W1645646323 @default.
- W2103307139 cites W1786883295 @default.
- W2103307139 cites W1964691336 @default.
- W2103307139 cites W1965613016 @default.
- W2103307139 cites W1966370450 @default.
- W2103307139 cites W1967971429 @default.
- W2103307139 cites W1969675752 @default.
- W2103307139 cites W1970649373 @default.
- W2103307139 cites W1973500525 @default.
- W2103307139 cites W1980886592 @default.
- W2103307139 cites W1987380844 @default.
- W2103307139 cites W1991258133 @default.
- W2103307139 cites W1996463845 @default.
- W2103307139 cites W2012916233 @default.
- W2103307139 cites W2013494309 @default.
- W2103307139 cites W2015531187 @default.
- W2103307139 cites W2033767254 @default.
- W2103307139 cites W2034442000 @default.
- W2103307139 cites W2039297053 @default.
- W2103307139 cites W2043776462 @default.
- W2103307139 cites W2044341880 @default.
- W2103307139 cites W2045491221 @default.
- W2103307139 cites W2050936670 @default.
- W2103307139 cites W2054942795 @default.
- W2103307139 cites W2056033105 @default.
- W2103307139 cites W2061562309 @default.
- W2103307139 cites W2071281521 @default.
- W2103307139 cites W2082075917 @default.
- W2103307139 cites W2084882261 @default.
- W2103307139 cites W2088552818 @default.
- W2103307139 cites W2092966687 @default.
- W2103307139 cites W2096484483 @default.
- W2103307139 cites W2099825600 @default.
- W2103307139 cites W2100136475 @default.
- W2103307139 cites W2100307219 @default.
- W2103307139 cites W2106883624 @default.
- W2103307139 cites W2113380083 @default.
- W2103307139 cites W2115764086 @default.
- W2103307139 cites W2118129611 @default.
- W2103307139 cites W2120498539 @default.
- W2103307139 cites W2121323579 @default.
- W2103307139 cites W2121858254 @default.
- W2103307139 cites W2132080719 @default.
- W2103307139 cites W2133289340 @default.
- W2103307139 cites W2135817940 @default.
- W2103307139 cites W2137723669 @default.
- W2103307139 cites W2142751122 @default.
- W2103307139 cites W2151410975 @default.
- W2103307139 cites W2160066010 @default.
- W2103307139 cites W2160340404 @default.
- W2103307139 cites W2168875502 @default.
- W2103307139 cites W2171877002 @default.
- W2103307139 cites W2319831517 @default.
- W2103307139 cites W2333608599 @default.
- W2103307139 cites W2388163742 @default.
- W2103307139 cites W2414225475 @default.
- W2103307139 cites W29325754 @default.
- W2103307139 doi "https://doi.org/10.1093/carcin/bgs176" @default.
- W2103307139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22623646" @default.
- W2103307139 hasPublicationYear "2012" @default.
- W2103307139 type Work @default.
- W2103307139 sameAs 2103307139 @default.
- W2103307139 citedByCount "33" @default.
- W2103307139 countsByYear W21033071392013 @default.
- W2103307139 countsByYear W21033071392014 @default.
- W2103307139 countsByYear W21033071392015 @default.
- W2103307139 countsByYear W21033071392016 @default.
- W2103307139 countsByYear W21033071392017 @default.
- W2103307139 countsByYear W21033071392019 @default.
- W2103307139 countsByYear W21033071392020 @default.
- W2103307139 countsByYear W21033071392021 @default.
- W2103307139 countsByYear W21033071392022 @default.
- W2103307139 countsByYear W21033071392023 @default.
- W2103307139 crossrefType "journal-article" @default.
- W2103307139 hasAuthorship W2103307139A5017542401 @default.
- W2103307139 hasAuthorship W2103307139A5029217625 @default.
- W2103307139 hasAuthorship W2103307139A5038929958 @default.
- W2103307139 hasAuthorship W2103307139A5051516116 @default.
- W2103307139 hasAuthorship W2103307139A5056464877 @default.
- W2103307139 hasAuthorship W2103307139A5059066999 @default.
- W2103307139 hasAuthorship W2103307139A5063985660 @default.
- W2103307139 hasAuthorship W2103307139A5079853904 @default.