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• W2103308013 abstract "Article history Gastroretentive floating tablets of atorvastatin calcium were formulated by using synthetic and natural polymers like HPMC and guar gum, Xanthan gum, karaya gum, aleovera powder respectively in order to enhance the bioavailability (14%) of atorvastatin calcium a drug used in the treatment of dyslipidemia and for the prevention of cardiovascular diseases. Floating tablets were prepared by employing potassium bicarbonate as a gas generating agent, and Polyvinylpyrrolidone K-30 as binder and excipients like Micro crystalline cellulose, dibasic calcium phosphate, magnesium stearate and talc. Tablets were prepared by direct compression method and the prepared tablets were evaluated for pre-compression characteristics and post- compression characteristics like weight variation, hardness, thickness, friability, swelling index, floating lag time, floating duration and in-vitro dissolution studies. FTIR studies for the drug and polymers shows that they are compatible. The precompression parameters indicate good flow properties for the powder. The tablets formulated with synthetic polymers remained buoyant for more than 6hrs and those with natural polymer remained for more than 8hrs in the release media. The optimized formulation F6 remains floating for more than 12 hrs and shows a sustained release of drug and percentage of drug release after 12 hrs was found to be 95.92%. The drug release mechanism for the optimized formula is by Higuchi's model (R 2 = 0.9987). DSC studies have shown that drug is stable in the formulation. It is concluded that the natural polymers are more effective than the synthetic polymers in the development of gastroretentive dosage forms and thus enhances the solubility and bioavailability of the drug." @default.
• W2103308013 created "2016-06-24" @default.
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• W2103308013 date "2013-01-01" @default.
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• W2103308013 title "FUNCTIONALITY COMPARISON BETWEEN NATURAL AND SYNTHETIC POLYMERS IN DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM OF ATORVASTATIN CALCIUM" @default.
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