Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103308950> ?p ?o ?g. }
- W2103308950 endingPage "2395" @default.
- W2103308950 startingPage "2383" @default.
- W2103308950 abstract "Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFbeta genes. We determined the characteristic gene expression profile of DFSP and characterized DNA copy number changes in DFSP by array-based comparative genomic hybridization (array CGH). Fresh frozen and formalin-fixed, paraffin-embedded samples of DFSP were analyzed by array CGH (four cases) and DNA microarray analysis of global gene expression (nine cases). The nine DFSPs were readily distinguished from 27 other diverse soft tissue tumors based on their gene expression patterns. Genes characteristically expressed in the DFSPs included PDGF beta and its receptor, PDGFRB, APOD, MEOX1, PLA2R, and PRKCA. Array CGH of DNA extracted either from frozen tumor samples or from paraffin blocks yielded equivalent results. Large areas of chromosomes 17q and 22q, bounded by COL1A1 and PDGF beta, respectively, were amplified in DFSP. Expression of genes in the amplified regions was significantly elevated. Our data shows that: 1) DFSP has a distinctive gene expression profile; 2) array CGH can be applied successfully to frozen or formalin-fixed, paraffin-embedded tumor samples; 3) a characteristic amplification of sequences from chromosomes 17q and 22q, demarcated by the COL1A1 and PDGF beta genes, respectively, was associated with elevated expression of the amplified genes." @default.
- W2103308950 created "2016-06-24" @default.
- W2103308950 creator A5001267176 @default.
- W2103308950 creator A5006583313 @default.
- W2103308950 creator A5008936074 @default.
- W2103308950 creator A5009124370 @default.
- W2103308950 creator A5016933339 @default.
- W2103308950 creator A5023944464 @default.
- W2103308950 creator A5035091786 @default.
- W2103308950 creator A5035251468 @default.
- W2103308950 creator A5045148327 @default.
- W2103308950 creator A5063917865 @default.
- W2103308950 creator A5065751654 @default.
- W2103308950 creator A5065906655 @default.
- W2103308950 creator A5077542898 @default.
- W2103308950 creator A5078993134 @default.
- W2103308950 date "2003-12-01" @default.
- W2103308950 modified "2023-10-14" @default.
- W2103308950 title "Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans" @default.
- W2103308950 cites W1208928033 @default.
- W2103308950 cites W1540592419 @default.
- W2103308950 cites W1548932088 @default.
- W2103308950 cites W1592526217 @default.
- W2103308950 cites W1635421292 @default.
- W2103308950 cites W1727290854 @default.
- W2103308950 cites W1965952833 @default.
- W2103308950 cites W1971659096 @default.
- W2103308950 cites W1973032082 @default.
- W2103308950 cites W1973607853 @default.
- W2103308950 cites W1988078905 @default.
- W2103308950 cites W2000771269 @default.
- W2103308950 cites W2011683291 @default.
- W2103308950 cites W2012615817 @default.
- W2103308950 cites W2015551422 @default.
- W2103308950 cites W2024129238 @default.
- W2103308950 cites W2024971989 @default.
- W2103308950 cites W2032163170 @default.
- W2103308950 cites W2032412341 @default.
- W2103308950 cites W2034245746 @default.
- W2103308950 cites W2036902495 @default.
- W2103308950 cites W2040316588 @default.
- W2103308950 cites W2044702943 @default.
- W2103308950 cites W2046841776 @default.
- W2103308950 cites W2049871756 @default.
- W2103308950 cites W2051678123 @default.
- W2103308950 cites W2052144833 @default.
- W2103308950 cites W2068752797 @default.
- W2103308950 cites W2072848377 @default.
- W2103308950 cites W2074644169 @default.
- W2103308950 cites W2083461667 @default.
- W2103308950 cites W2088851040 @default.
- W2103308950 cites W2097255042 @default.
- W2103308950 cites W2100417824 @default.
- W2103308950 cites W2100555004 @default.
- W2103308950 cites W2102090584 @default.
- W2103308950 cites W2117190895 @default.
- W2103308950 cites W2123639075 @default.
- W2103308950 cites W2131994307 @default.
- W2103308950 cites W2140626630 @default.
- W2103308950 cites W2147246240 @default.
- W2103308950 cites W2147347845 @default.
- W2103308950 cites W2149393207 @default.
- W2103308950 cites W2150926065 @default.
- W2103308950 cites W2152002438 @default.
- W2103308950 cites W2154361640 @default.
- W2103308950 cites W2157477905 @default.
- W2103308950 cites W2157795344 @default.
- W2103308950 cites W2159400887 @default.
- W2103308950 cites W2248643920 @default.
- W2103308950 cites W2259802687 @default.
- W2103308950 cites W2290492091 @default.
- W2103308950 cites W23753455 @default.
- W2103308950 cites W2407977596 @default.
- W2103308950 cites W4246697467 @default.
- W2103308950 cites W4294107304 @default.
- W2103308950 cites W83175001 @default.
- W2103308950 cites W91141168 @default.
- W2103308950 doi "https://doi.org/10.1016/s0002-9440(10)63593-6" @default.
- W2103308950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1892373" @default.
- W2103308950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14633610" @default.
- W2103308950 hasPublicationYear "2003" @default.
- W2103308950 type Work @default.
- W2103308950 sameAs 2103308950 @default.
- W2103308950 citedByCount "132" @default.
- W2103308950 countsByYear W21033089502012 @default.
- W2103308950 countsByYear W21033089502013 @default.
- W2103308950 countsByYear W21033089502014 @default.
- W2103308950 countsByYear W21033089502015 @default.
- W2103308950 countsByYear W21033089502016 @default.
- W2103308950 countsByYear W21033089502017 @default.
- W2103308950 countsByYear W21033089502018 @default.
- W2103308950 countsByYear W21033089502019 @default.
- W2103308950 countsByYear W21033089502020 @default.
- W2103308950 countsByYear W21033089502021 @default.
- W2103308950 countsByYear W21033089502022 @default.
- W2103308950 countsByYear W21033089502023 @default.
- W2103308950 crossrefType "journal-article" @default.
- W2103308950 hasAuthorship W2103308950A5001267176 @default.