FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103309265> ?p ?o ?g. }

• W2103309265 endingPage "R226" @default.
• W2103309265 startingPage "R226" @default.
• W2103309265 abstract "Metformin associated lactic acidosis (MALA) may complicate metformin therapy, particularly if metformin accumulates due to renal dysfunction. Profound lactic acidosis (LA) generally predicts poor outcome. We aimed to determine if MALA differs in outcome from LA of other origin (LAOO). We conducted a retrospective analysis of all patients admitted with LA to our medical ICU of a tertiary referral center during a 5-year period. MALA patients and LAOO patients were compared with respect to parameters of acid-base balance, serum creatinine, hospital outcome, Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) score, using Pearson's Chi-square or the Mann-Whitney U-test. Of 197 patients admitted with LA, 10 had been diagnosed with MALA. With MALA, median arterial blood pH was significantly lower (6.78 [range 6.5 to 6.94]) and serum lactate significantly higher (18.7 ± 5.3 mmol/L) than with LAOO (pH 7.20 [range 6.46 to 7.35], mean serum lactate 11.2 ± 6.1 mmol/L). Overall mortality, however, was comparable (MALA 50%, LAOO 74%). Furthermore, survival of patients with arterial blood pH < 7.00 (N = 41) was significantly better (50% vs. 0%) if MALA (N = 10) was the underlying condition compared to LAOO (N = 31). Compared to similarly severe lactic acidosis of other origin, the prognosis of MALA is significantly better. MALA should be considered in metformin-treated patients presenting with lactic acidosis." @default.
• W2103309265 created "2016-06-24" @default.
• W2103309265 creator A5000760642 @default.
• W2103309265 creator A5051350683 @default.
• W2103309265 creator A5060792052 @default.
• W2103309265 creator A5068746352 @default.
• W2103309265 creator A5075690653 @default.
• W2103309265 date "2010-01-01" @default.
• W2103309265 modified "2023-10-01" @default.
• W2103309265 title "Outcome of severe lactic acidosis associated with metformin accumulation" @default.
• W2103309265 cites W1898928487 @default.
• W2103309265 cites W1965699597 @default.
• W2103309265 cites W1968748270 @default.
• W2103309265 cites W1973048382 @default.
• W2103309265 cites W1991864206 @default.
• W2103309265 cites W1994333190 @default.
• W2103309265 cites W1997224005 @default.
• W2103309265 cites W2000470447 @default.
• W2103309265 cites W2001225904 @default.
• W2103309265 cites W2014592786 @default.
• W2103309265 cites W2017242705 @default.
• W2103309265 cites W2021245895 @default.
• W2103309265 cites W2025117034 @default.
• W2103309265 cites W2046503553 @default.
• W2103309265 cites W2057842674 @default.
• W2103309265 cites W2059077146 @default.
• W2103309265 cites W2067068390 @default.
• W2103309265 cites W2076185134 @default.
• W2103309265 cites W2078508655 @default.
• W2103309265 cites W2108267669 @default.
• W2103309265 cites W2119254210 @default.
• W2103309265 cites W2122144516 @default.
• W2103309265 cites W2124086578 @default.
• W2103309265 cites W2128349740 @default.
• W2103309265 cites W2132406635 @default.
• W2103309265 cites W2136558866 @default.
• W2103309265 cites W2148672071 @default.
• W2103309265 cites W2160710729 @default.
• W2103309265 cites W2161987792 @default.
• W2103309265 cites W2170760052 @default.
• W2103309265 cites W2188846692 @default.
• W2103309265 cites W2242296801 @default.
• W2103309265 cites W2271771390 @default.
• W2103309265 doi "https://doi.org/10.1186/cc9376" @default.
• W2103309265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3220003" @default.
• W2103309265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21171991" @default.
• W2103309265 hasPublicationYear "2010" @default.
• W2103309265 type Work @default.
• W2103309265 sameAs 2103309265 @default.
• W2103309265 citedByCount "77" @default.
• W2103309265 countsByYear W21033092652012 @default.
• W2103309265 countsByYear W21033092652013 @default.
• W2103309265 countsByYear W21033092652014 @default.
• W2103309265 countsByYear W21033092652015 @default.
• W2103309265 countsByYear W21033092652016 @default.
• W2103309265 countsByYear W21033092652017 @default.
• W2103309265 countsByYear W21033092652018 @default.
• W2103309265 countsByYear W21033092652019 @default.
• W2103309265 countsByYear W21033092652020 @default.
• W2103309265 countsByYear W21033092652021 @default.
• W2103309265 countsByYear W21033092652022 @default.
• W2103309265 countsByYear W21033092652023 @default.
• W2103309265 crossrefType "journal-article" @default.
• W2103309265 hasAuthorship W2103309265A5000760642 @default.
• W2103309265 hasAuthorship W2103309265A5051350683 @default.
• W2103309265 hasAuthorship W2103309265A5060792052 @default.
• W2103309265 hasAuthorship W2103309265A5068746352 @default.
• W2103309265 hasAuthorship W2103309265A5075690653 @default.
• W2103309265 hasBestOaLocation W21033092651 @default.
• W2103309265 hasConcept C126322002 @default.
• W2103309265 hasConcept C167135981 @default.
• W2103309265 hasConcept C2775920511 @default.
• W2103309265 hasConcept C2778553927 @default.
• W2103309265 hasConcept C2779246250 @default.
• W2103309265 hasConcept C2779306644 @default.
• W2103309265 hasConcept C2779541074 @default.
• W2103309265 hasConcept C2780306776 @default.
• W2103309265 hasConcept C2780317664 @default.
• W2103309265 hasConcept C2780323712 @default.
• W2103309265 hasConcept C523546767 @default.
• W2103309265 hasConcept C54355233 @default.
• W2103309265 hasConcept C71924100 @default.
• W2103309265 hasConcept C86803240 @default.
• W2103309265 hasConcept C90924648 @default.
• W2103309265 hasConceptScore W2103309265C126322002 @default.
• W2103309265 hasConceptScore W2103309265C167135981 @default.
• W2103309265 hasConceptScore W2103309265C2775920511 @default.
• W2103309265 hasConceptScore W2103309265C2778553927 @default.
• W2103309265 hasConceptScore W2103309265C2779246250 @default.
• W2103309265 hasConceptScore W2103309265C2779306644 @default.
• W2103309265 hasConceptScore W2103309265C2779541074 @default.
• W2103309265 hasConceptScore W2103309265C2780306776 @default.
• W2103309265 hasConceptScore W2103309265C2780317664 @default.
• W2103309265 hasConceptScore W2103309265C2780323712 @default.
• W2103309265 hasConceptScore W2103309265C523546767 @default.
• W2103309265 hasConceptScore W2103309265C54355233 @default.
• W2103309265 hasConceptScore W2103309265C71924100 @default.
• W2103309265 hasConceptScore W2103309265C86803240 @default.

• next