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• W2103309443 abstract "To identify changes in expression of stimulatory and inhibitory factors when normal endometrium becomes menorrhagic.Retrospective blinded immunohistologic study.Private research center.Premenopausal and postmenopausal women with non-menorrhagic and menorrhagic endometrium undergoing curettage or hysterectomy were selected.Samples of endometrium were obtained from all patients.Expression of angiopoietins 1 and 2, and vascular receptors Tie-1 and Tie-2 and endothelial nitric oxide synthase (eNOS).Angiopoietin 1 (ANG-1) expression was similar in non-menorrhagic and menorrhagic endometrium. However, there was a significant increase in expression of ANG-2 and its receptor Tie-2 in menorrhagic tissues, which may be important in destabilizing the endometrial vasculature. Tie-1, responsible for endothelial integrity, was also increased in menorrhagic tissues, and is a likely compensatory mechanism for the existing vascular pathology. Expression of eNOS was also increased in menorrhagic women.Differences in the expression of ANG-2, Tie-2, Tie-1, and eNOS were found in menorrhagic endometrium, which may represent a new target for therapeutic intervention to correct menorrhagic conditions." @default.
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• W2103309443 date "2002-12-01" @default.
• W2103309443 modified "2023-09-27" @default.
• W2103309443 title "Abnormal expression of the angiopoietins and Tie receptors in menorrhagic endometrium" @default.
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• W2103309443 doi "https://doi.org/10.1016/s0015-0282(02)04276-0" @default.
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