FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103309568> ?p ?o ?g. }

• W2103309568 endingPage "R1302" @default.
• W2103309568 startingPage "R1296" @default.
• W2103309568 abstract "Mitochondria are crucial organelles in cell life serving as a source of energy production and as regulators of Ca(2+) homeostasis, apoptosis, and development. Mitochondria frequently change their shape by fusion and fission, and recent research on these morphological dynamics of mitochondria has highlighted their role in normal cell physiology and disease. In this study, we investigated the effect of high glucose on mitochondrial dynamics in neonatal cardiac myocytes (NCMs). High-glucose treatment of NCMs significantly decreased the level of optical atrophy 1 (OPA1) (mitochondrial fusion-related protein) protein expression. NCMs exhibit two different kinds of mitochondrial structure: round shape around the nuclear area and elongated tubular structures in the pseudopod area. High-glucose-treated NCMs exhibited augmented mitochondrial fragmentation in the pseudopod area. This effect was significantly decreased by OPA1 overexpression. High-glucose exposure also led to increased O-GlcNAcylation of OPA1 in NCMs. GlcNAcase (GCA) overexpression in high-glucose-treated NCMs decreased OPA1 protein O-GlcNAcylation and significantly increased mitochondrial elongation. In addition to the morphological change caused by high glucose, we observed that high glucose decreased mitochondrial membrane potential and complex IV activity and that OPA1 overexpression increased both levels to the control level. These data suggest that decreased OPA1 protein level and increased O-GlcNAcylation of OPA1 protein by high glucose lead to mitochondrial dysfunction by increasing mitochondrial fragmentation, decreasing mitochondrial membrane potential, and attenuating the activity of mitochondrial complex IV, and that overexpression of OPA1 and GCA in cardiac myocytes may help improve the cardiac dysfunction in diabetes." @default.
• W2103309568 created "2016-06-24" @default.
• W2103309568 creator A5028383680 @default.
• W2103309568 creator A5029880524 @default.
• W2103309568 creator A5031145772 @default.
• W2103309568 creator A5033020983 @default.
• W2103309568 creator A5056829553 @default.
• W2103309568 creator A5069174429 @default.
• W2103309568 creator A5080877331 @default.
• W2103309568 date "2011-06-01" @default.
• W2103309568 modified "2023-10-05" @default.
• W2103309568 title "Regulation of mitochondrial morphology and function by <i>O</i>-GlcNAcylation in neonatal cardiac myocytes" @default.
• W2103309568 cites W1554250492 @default.
• W2103309568 cites W1561484646 @default.
• W2103309568 cites W1984824196 @default.
• W2103309568 cites W1986721569 @default.
• W2103309568 cites W1989540421 @default.
• W2103309568 cites W2000325349 @default.
• W2103309568 cites W2014115155 @default.
• W2103309568 cites W2014777707 @default.
• W2103309568 cites W2028762215 @default.
• W2103309568 cites W2030145039 @default.
• W2103309568 cites W2033515015 @default.
• W2103309568 cites W2041061895 @default.
• W2103309568 cites W2041967294 @default.
• W2103309568 cites W2044924691 @default.
• W2103309568 cites W2045726869 @default.
• W2103309568 cites W2047754708 @default.
• W2103309568 cites W2060811345 @default.
• W2103309568 cites W2067423895 @default.
• W2103309568 cites W2070208185 @default.
• W2103309568 cites W2072087702 @default.
• W2103309568 cites W2073095545 @default.
• W2103309568 cites W2073296546 @default.
• W2103309568 cites W2076420512 @default.
• W2103309568 cites W2083698829 @default.
• W2103309568 cites W2085035881 @default.
• W2103309568 cites W2094113524 @default.
• W2103309568 cites W2096983674 @default.
• W2103309568 cites W2102626915 @default.
• W2103309568 cites W2102916729 @default.
• W2103309568 cites W2104828119 @default.
• W2103309568 cites W2105754268 @default.
• W2103309568 cites W2113716304 @default.
• W2103309568 cites W2114651986 @default.
• W2103309568 cites W2125206853 @default.
• W2103309568 cites W2127271204 @default.
• W2103309568 cites W2127806759 @default.
• W2103309568 cites W2131666074 @default.
• W2103309568 cites W2132579877 @default.
• W2103309568 cites W2136937485 @default.
• W2103309568 cites W2144174954 @default.
• W2103309568 cites W2146173783 @default.
• W2103309568 cites W2146302436 @default.
• W2103309568 cites W2149128081 @default.
• W2103309568 cites W2158264554 @default.
• W2103309568 cites W2164174765 @default.
• W2103309568 cites W2164548243 @default.
• W2103309568 cites W2164698588 @default.
• W2103309568 cites W2165283489 @default.
• W2103309568 cites W2168136518 @default.
• W2103309568 doi "https://doi.org/10.1152/ajpregu.00437.2010" @default.
• W2103309568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119148" @default.
• W2103309568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21346246" @default.
• W2103309568 hasPublicationYear "2011" @default.
• W2103309568 type Work @default.
• W2103309568 sameAs 2103309568 @default.
• W2103309568 citedByCount "86" @default.
• W2103309568 countsByYear W21033095682012 @default.
• W2103309568 countsByYear W21033095682013 @default.
• W2103309568 countsByYear W21033095682014 @default.
• W2103309568 countsByYear W21033095682015 @default.
• W2103309568 countsByYear W21033095682016 @default.
• W2103309568 countsByYear W21033095682017 @default.
• W2103309568 countsByYear W21033095682018 @default.
• W2103309568 countsByYear W21033095682019 @default.
• W2103309568 countsByYear W21033095682020 @default.
• W2103309568 countsByYear W21033095682021 @default.
• W2103309568 countsByYear W21033095682022 @default.
• W2103309568 countsByYear W21033095682023 @default.
• W2103309568 crossrefType "journal-article" @default.
• W2103309568 hasAuthorship W2103309568A5028383680 @default.
• W2103309568 hasAuthorship W2103309568A5029880524 @default.
• W2103309568 hasAuthorship W2103309568A5031145772 @default.
• W2103309568 hasAuthorship W2103309568A5033020983 @default.
• W2103309568 hasAuthorship W2103309568A5056829553 @default.
• W2103309568 hasAuthorship W2103309568A5069174429 @default.
• W2103309568 hasAuthorship W2103309568A5080877331 @default.
• W2103309568 hasBestOaLocation W21033095682 @default.
• W2103309568 hasConcept C104317684 @default.
• W2103309568 hasConcept C126322002 @default.
• W2103309568 hasConcept C134018914 @default.
• W2103309568 hasConcept C163950672 @default.
• W2103309568 hasConcept C17619807 @default.
• W2103309568 hasConcept C207200792 @default.
• W2103309568 hasConcept C24586158 @default.
• W2103309568 hasConcept C2777755479 @default.
• W2103309568 hasConcept C28859421 @default.

• next