Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103311193> ?p ?o ?g. }
- W2103311193 endingPage "583" @default.
- W2103311193 startingPage "555" @default.
- W2103311193 abstract "Numerous nucleic acid ligands, also termed decoys or aptamers, have been developed during the past 15 years that can inhibit the activity of many pathogenic proteins. Two of them, Macugen and E2F decoy, are in phase III clinical trials. Several properties of aptamers make them an attractive class of therapeutic compounds. Their affinity and specificity for a given protein make it possible to isolate a ligand to virtually any target, and adjusting their bioavailability expands their clinical utility. The ability to develop aptamers that retain activity in multiple organisms facilitates preclinical development. Antidote control of aptamer activity enables safe, tightly controlled therapeutics. Aptamers may prove useful in the treatment of a wide variety of human maladies, including infectious diseases, cancer, and cardiovascular disease. We review the observations that facilitated the development of this emerging class of therapeutics, summarize progress to date, and speculate on the eventual utility of such agents in the clinic." @default.
- W2103311193 created "2016-06-24" @default.
- W2103311193 creator A5008411097 @default.
- W2103311193 creator A5016424099 @default.
- W2103311193 creator A5040370918 @default.
- W2103311193 date "2005-02-01" @default.
- W2103311193 modified "2023-10-14" @default.
- W2103311193 title "Aptamers: An Emerging Class of Therapeutics" @default.
- W2103311193 cites W1489870404 @default.
- W2103311193 cites W1512165930 @default.
- W2103311193 cites W1523207280 @default.
- W2103311193 cites W1545547564 @default.
- W2103311193 cites W1556322054 @default.
- W2103311193 cites W1572649493 @default.
- W2103311193 cites W1599096467 @default.
- W2103311193 cites W1599302006 @default.
- W2103311193 cites W1811402656 @default.
- W2103311193 cites W1831899038 @default.
- W2103311193 cites W1888783223 @default.
- W2103311193 cites W1964858690 @default.
- W2103311193 cites W1967004211 @default.
- W2103311193 cites W1968405341 @default.
- W2103311193 cites W1970032949 @default.
- W2103311193 cites W1970076580 @default.
- W2103311193 cites W1971204919 @default.
- W2103311193 cites W1972380844 @default.
- W2103311193 cites W1972809036 @default.
- W2103311193 cites W1973950849 @default.
- W2103311193 cites W1977029770 @default.
- W2103311193 cites W1978202265 @default.
- W2103311193 cites W1980230083 @default.
- W2103311193 cites W1980585134 @default.
- W2103311193 cites W1990367169 @default.
- W2103311193 cites W1991178545 @default.
- W2103311193 cites W1992346069 @default.
- W2103311193 cites W1999876280 @default.
- W2103311193 cites W2002008977 @default.
- W2103311193 cites W2007499397 @default.
- W2103311193 cites W2009526923 @default.
- W2103311193 cites W2012094473 @default.
- W2103311193 cites W2012255417 @default.
- W2103311193 cites W2027835440 @default.
- W2103311193 cites W2027937758 @default.
- W2103311193 cites W2029400685 @default.
- W2103311193 cites W2035413582 @default.
- W2103311193 cites W2038167103 @default.
- W2103311193 cites W2038894713 @default.
- W2103311193 cites W2039624553 @default.
- W2103311193 cites W2041887649 @default.
- W2103311193 cites W2045812040 @default.
- W2103311193 cites W2048079618 @default.
- W2103311193 cites W2056285082 @default.
- W2103311193 cites W2056866177 @default.
- W2103311193 cites W2058590056 @default.
- W2103311193 cites W2061256231 @default.
- W2103311193 cites W2062235055 @default.
- W2103311193 cites W2067885827 @default.
- W2103311193 cites W2071745634 @default.
- W2103311193 cites W2073813525 @default.
- W2103311193 cites W2079321730 @default.
- W2103311193 cites W2080385324 @default.
- W2103311193 cites W2084208256 @default.
- W2103311193 cites W2085295620 @default.
- W2103311193 cites W2085383736 @default.
- W2103311193 cites W2086127405 @default.
- W2103311193 cites W2086547881 @default.
- W2103311193 cites W2087146563 @default.
- W2103311193 cites W2091695331 @default.
- W2103311193 cites W2092357174 @default.
- W2103311193 cites W2099955234 @default.
- W2103311193 cites W2104525153 @default.
- W2103311193 cites W2109764004 @default.
- W2103311193 cites W2110030647 @default.
- W2103311193 cites W2110826816 @default.
- W2103311193 cites W2116169737 @default.
- W2103311193 cites W2117984921 @default.
- W2103311193 cites W2122278806 @default.
- W2103311193 cites W2122570947 @default.
- W2103311193 cites W2137893922 @default.
- W2103311193 cites W2138495171 @default.
- W2103311193 cites W2142376043 @default.
- W2103311193 cites W2147231986 @default.
- W2103311193 cites W2156367667 @default.
- W2103311193 cites W2162417096 @default.
- W2103311193 cites W2166447832 @default.
- W2103311193 cites W2172776197 @default.
- W2103311193 cites W2185838453 @default.
- W2103311193 cites W2256946804 @default.
- W2103311193 cites W2314045451 @default.
- W2103311193 cites W2318511239 @default.
- W2103311193 cites W2612281319 @default.
- W2103311193 cites W2612675835 @default.
- W2103311193 cites W4210950852 @default.
- W2103311193 cites W4246991801 @default.
- W2103311193 cites W4248406156 @default.
- W2103311193 cites W4252287408 @default.
- W2103311193 cites W4376453214 @default.
- W2103311193 cites W79630512 @default.