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- W2103316970 abstract "B-lineage–committed cells are believed to arise in the liver of mouse embryos at 14 days after coitus (dpc). However, pre-B-specific gene transcripts and DJH gene rearrangements have been detected in earlier, midgestation embryos. We describe here a population of c-kit+AA4.1+CD19+Pax5+cells present in the aorta-gonad-mesonephros (AGM) area and in the livers of 11-dpc mouse embryos. In contrast to multipotent c-kit+AA4.1+CD19−hematopoietic stem cells (HSCs), these c-kit+AA4.1+CD19+ progenitors differentiated only to B-lineage cells in vitro. We propose that mouse embryonic B lymphopoiesis starts earlier than previously thought, at 10 to 11 dpc, both in liver and extra-liver hematopoietic sites. The B-cell differentiation program is not delayed with respect to the emerging lymphohematopoiesis events in the midgestation mouse embryo (8-9 dpc)." @default.
- W2103316970 created "2016-06-24" @default.
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- W2103316970 date "2002-12-01" @default.
- W2103316970 modified "2023-10-17" @default.
- W2103316970 title "The first 3 days of B-cell development in the mouse embryo" @default.
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- W2103316970 doi "https://doi.org/10.1182/blood-2002-03-0809" @default.
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