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- W2103319593 abstract "Fas is a membrane protein belonging to the death receptor family. Cross-linking of Fas by its ligand, FasL, or agonistic anti-Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies may be a promising anticancer therapy. Unfortunately, not all Fas-expressing cells are sensitive to Fas-mediated apoptosis. This has resulted in the discovery of many different inhibition mechanisms of Fas-mediated apoptosis. In addition, mutations in the Fas or p53 gene can also influence the sensitivity for Fas-mediated apoptosis. However, the role of wild-type p53 in Fas expression is still controversial. Because several different cytotoxic drugs are able to induce Fas membrane expression, combination therapy of anticancer drugs with anti-Fas antibodies or FasL is conceivable as an anticancer strategy. The efficiency of the induction of Fas-mediated apoptosis by anti-Fas antibodies, FasL-expressing cells or recombinant FasL (rFasL) in tumours has been demonstrated in vivo in solid tumours implanted in mice. Unfortunately, systemic treatment with anti-Fas antibodies or rFasL causes severe damage to the liver, so most preclinical studies are now focusing on circumvention of this problem by local administration of FasL, or on the use of inducible FasL-expressing vectors as gene therapy." @default.
- W2103319593 created "2016-06-24" @default.
- W2103319593 creator A5051509827 @default.
- W2103319593 creator A5061495577 @default.
- W2103319593 creator A5080880631 @default.
- W2103319593 date "2002-01-01" @default.
- W2103319593 modified "2023-09-30" @default.
- W2103319593 title "Fas receptor-mediated apoptosis: a clinical application?" @default.
- W2103319593 cites W105127712 @default.
- W2103319593 cites W1485786017 @default.
- W2103319593 cites W1529544531 @default.
- W2103319593 cites W1557686543 @default.
- W2103319593 cites W1558473055 @default.
- W2103319593 cites W1558865081 @default.
- W2103319593 cites W1561515054 @default.
- W2103319593 cites W1591166893 @default.
- W2103319593 cites W1598719623 @default.
- W2103319593 cites W1662819364 @default.
- W2103319593 cites W1678355196 @default.
- W2103319593 cites W1836073275 @default.
- W2103319593 cites W1942214720 @default.
- W2103319593 cites W1966178583 @default.
- W2103319593 cites W1969122129 @default.
- W2103319593 cites W1970770376 @default.
- W2103319593 cites W1972805802 @default.
- W2103319593 cites W1973109581 @default.
- W2103319593 cites W1973792489 @default.
- W2103319593 cites W1976226379 @default.
- W2103319593 cites W1976692354 @default.
- W2103319593 cites W1977499961 @default.
- W2103319593 cites W1978018492 @default.
- W2103319593 cites W1978162067 @default.
- W2103319593 cites W1979842763 @default.
- W2103319593 cites W1979995768 @default.
- W2103319593 cites W1980919524 @default.
- W2103319593 cites W1982213879 @default.
- W2103319593 cites W1982661150 @default.
- W2103319593 cites W1984894292 @default.
- W2103319593 cites W1985603468 @default.
- W2103319593 cites W1988064124 @default.
- W2103319593 cites W1989600187 @default.
- W2103319593 cites W1989864703 @default.
- W2103319593 cites W1990522751 @default.
- W2103319593 cites W1991865867 @default.
- W2103319593 cites W1993199753 @default.
- W2103319593 cites W1997296950 @default.
- W2103319593 cites W2002503549 @default.
- W2103319593 cites W2002507218 @default.
- W2103319593 cites W2005482741 @default.
- W2103319593 cites W2006973295 @default.
- W2103319593 cites W2011369627 @default.
- W2103319593 cites W2012173926 @default.
- W2103319593 cites W2016198585 @default.
- W2103319593 cites W2017578232 @default.
- W2103319593 cites W2017728303 @default.
- W2103319593 cites W2022015605 @default.
- W2103319593 cites W2022923458 @default.
- W2103319593 cites W2025559703 @default.
- W2103319593 cites W2029788866 @default.
- W2103319593 cites W2032417513 @default.
- W2103319593 cites W2034518877 @default.
- W2103319593 cites W2034520597 @default.
- W2103319593 cites W2037079046 @default.
- W2103319593 cites W2041466047 @default.
- W2103319593 cites W2042811848 @default.
- W2103319593 cites W2045068005 @default.
- W2103319593 cites W2045796964 @default.
- W2103319593 cites W2045923190 @default.
- W2103319593 cites W2047056744 @default.
- W2103319593 cites W2047477069 @default.
- W2103319593 cites W2049110705 @default.
- W2103319593 cites W2050671044 @default.
- W2103319593 cites W2053178768 @default.
- W2103319593 cites W2058591356 @default.
- W2103319593 cites W2060285901 @default.
- W2103319593 cites W2060683243 @default.
- W2103319593 cites W2062853648 @default.
- W2103319593 cites W2064982197 @default.
- W2103319593 cites W2067534266 @default.
- W2103319593 cites W2068315718 @default.
- W2103319593 cites W2070862399 @default.
- W2103319593 cites W2073096708 @default.
- W2103319593 cites W2075809552 @default.
- W2103319593 cites W2076229621 @default.
- W2103319593 cites W2077856196 @default.
- W2103319593 cites W2078297328 @default.
- W2103319593 cites W2081511824 @default.
- W2103319593 cites W2083363077 @default.
- W2103319593 cites W2083765379 @default.
- W2103319593 cites W2083906562 @default.
- W2103319593 cites W2086088023 @default.
- W2103319593 cites W2087013919 @default.
- W2103319593 cites W2087079563 @default.
- W2103319593 cites W2087936235 @default.
- W2103319593 cites W2092589738 @default.
- W2103319593 cites W2094334993 @default.
- W2103319593 cites W2096950793 @default.
- W2103319593 cites W2098593116 @default.