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- W2103332964 abstract "Homeobox genes encode a large superclass of transcription factors with widespread roles in animal development. Within chordates there are over 100 homeobox genes in the invertebrate cephalochordate amphioxus and over 200 in humans. Set against this general trend of increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from vertebrates. Here, we describe the embryonic expression of four amphioxus descendants of these genes— AmphiNedxa, AmphiNedxb, AmphiMsxlx and AmphiNKx7 . All four genes are expressed with a striking asymmetry about the left–right axis in the pharyngeal region of neurula embryos, mirroring the pronounced asymmetry of amphioxus embryogenesis. AmphiMsxlx and AmphiNKx7 are also transiently expressed in an anterior neural tube region destined to become the cerebral vesicle. These findings suggest significant rewiring of developmental gene regulatory networks occurred during chordate evolution, coincident with homeobox gene loss. We propose that loss of otherwise widely conserved genes is possible when these genes function in a confined role in development that is subsequently lost or significantly modified during evolution. In the case of these homeobox genes, we propose that this has occurred in relation to the evolution of the chordate pharynx and brain." @default.
- W2103332964 created "2016-06-24" @default.
- W2103332964 creator A5014330394 @default.
- W2103332964 creator A5028356669 @default.
- W2103332964 creator A5086873853 @default.
- W2103332964 date "2010-06-16" @default.
- W2103332964 modified "2023-10-11" @default.
- W2103332964 title "Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression" @default.
- W2103332964 cites W1524597810 @default.
- W2103332964 cites W1615515432 @default.
- W2103332964 cites W1913764014 @default.
- W2103332964 cites W1972491673 @default.
- W2103332964 cites W1974192701 @default.
- W2103332964 cites W1977224729 @default.
- W2103332964 cites W1977673144 @default.
- W2103332964 cites W1978591647 @default.
- W2103332964 cites W1980276479 @default.
- W2103332964 cites W1980850880 @default.
- W2103332964 cites W1981048058 @default.
- W2103332964 cites W1983111383 @default.
- W2103332964 cites W1989681239 @default.
- W2103332964 cites W1990742741 @default.
- W2103332964 cites W1991836440 @default.
- W2103332964 cites W1992139027 @default.
- W2103332964 cites W1995207946 @default.
- W2103332964 cites W1997035797 @default.
- W2103332964 cites W1998812124 @default.
- W2103332964 cites W2004081309 @default.
- W2103332964 cites W2008612038 @default.
- W2103332964 cites W2008635276 @default.
- W2103332964 cites W2009371644 @default.
- W2103332964 cites W2013806415 @default.
- W2103332964 cites W2015229831 @default.
- W2103332964 cites W2028937229 @default.
- W2103332964 cites W2033274498 @default.
- W2103332964 cites W2042224175 @default.
- W2103332964 cites W2044082480 @default.
- W2103332964 cites W2046791884 @default.
- W2103332964 cites W2047405437 @default.
- W2103332964 cites W2052219138 @default.
- W2103332964 cites W2055701763 @default.
- W2103332964 cites W2055846749 @default.
- W2103332964 cites W2056187821 @default.
- W2103332964 cites W2056593287 @default.
- W2103332964 cites W2059631454 @default.
- W2103332964 cites W2062269190 @default.
- W2103332964 cites W2062955619 @default.
- W2103332964 cites W2064422511 @default.
- W2103332964 cites W2065515897 @default.
- W2103332964 cites W2065818609 @default.
- W2103332964 cites W2066907134 @default.
- W2103332964 cites W2068845722 @default.
- W2103332964 cites W2070632854 @default.
- W2103332964 cites W2074561828 @default.
- W2103332964 cites W2078833721 @default.
- W2103332964 cites W2089161588 @default.
- W2103332964 cites W2092861842 @default.
- W2103332964 cites W2093219980 @default.
- W2103332964 cites W2102208272 @default.
- W2103332964 cites W2107344829 @default.
- W2103332964 cites W2108230386 @default.
- W2103332964 cites W2116015974 @default.
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- W2103332964 cites W2120071370 @default.
- W2103332964 cites W2122878396 @default.
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- W2103332964 cites W2129829180 @default.
- W2103332964 cites W2131871062 @default.
- W2103332964 cites W2135271831 @default.
- W2103332964 cites W2135740919 @default.
- W2103332964 cites W2148461722 @default.
- W2103332964 cites W2149583826 @default.
- W2103332964 cites W2149820875 @default.
- W2103332964 cites W2152839099 @default.
- W2103332964 cites W2160125070 @default.
- W2103332964 cites W2162768709 @default.
- W2103332964 cites W2183454611 @default.
- W2103332964 cites W2223071885 @default.
- W2103332964 cites W2263049155 @default.
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- W2103332964 doi "https://doi.org/10.1098/rspb.2010.0647" @default.
- W2103332964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2982225" @default.
- W2103332964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20554554" @default.
- W2103332964 hasPublicationYear "2010" @default.
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