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• W2103335669 abstract "ABSTRACT AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae . Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indicated that AG205 exerts antibacterial activity against S. pneumoniae through the specific inhibition of FabK." @default.
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• W2103335669 date "2006-08-01" @default.
• W2103335669 modified "2023-10-18" @default.
• W2103335669 title "AG205, a Novel Agent Directed against FabK of <i>Streptococcus pneumoniae</i>" @default.
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• W2103335669 doi "https://doi.org/10.1128/aac.00270-06" @default.
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