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- W2103351815 abstract "Bisphenol A (BPA) is a ubiquitous environmental endocrine disrupting compound (EDC); public health concerns have been fueled by findings that maternal BPA exposure can change sex differences in the brain and in some behaviors. We investigated whether a physiologically relevant dose of BPA ingested by male rats before conception would affect spatial memory and hippocampal acetylcholinesterase (AchE) in their adult offspring. Twenty-two 60-day-old male rats (F0) received either a BPA diet (50 μg/kg/day) or vehicle alone for 10 weeks before being mated with non-exposed females. The paternal rats and their forty adult offspring's (F1) behaviors were then examined in the Morris Water Maze (MWM) and their AchE activities in the hippocampus were evaluated. BPA exposure led to spatial memory deficits along with decreased AchE activities in the hippocampus (p = 0.01) in adult F0 rats. This paternal exposure also induced impairment in spatial memory acquisition in both sexes while retention only in females in F1 rats, as well as abolished sex differences in the hippocampus AchE. Overall, these data provide new evidence that paternal BPA exposure, at a “safe” dose, may induce transgenerational alterations in spatial memory in a sex-specific manner." @default.
- W2103351815 created "2016-06-24" @default.
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- W2103351815 date "2013-09-01" @default.
- W2103351815 modified "2023-10-16" @default.
- W2103351815 title "Does preconception paternal exposure to a physiologically relevant level of bisphenol A alter spatial memory in an adult rat?" @default.
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- W2103351815 doi "https://doi.org/10.1016/j.yhbeh.2013.08.014" @default.
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