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- W2103353268 endingPage "449" @default.
- W2103353268 startingPage "425" @default.
- W2103353268 abstract "Inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) exhibit stereotyped traits that are variably expressed in each person. In experimental mouse models of chronic lung disease, these individual disease traits can be genetically segregated and thereby linked to distinct determinants. Functional genomic analysis indicates that at least one of these traits, mucous cell metaplasia, depends on members of the calcium-activated chloride channel (CLCA) gene family. Here we review advances in the biochemistry of the CLCA family and the evidence of a role for CLCA family members in the development of mucous cell metaplasia and possibly airway hyperreactivity in experimental models and in humans. On the basis of this information, we develop the model that CLCA proteins are not integral membrane proteins with ion channel function but instead are secreted signaling molecules that specifically regulate airway target cells in healthy and disease conditions." @default.
- W2103353268 created "2016-06-24" @default.
- W2103353268 creator A5008809883 @default.
- W2103353268 creator A5036584012 @default.
- W2103353268 creator A5053701210 @default.
- W2103353268 date "2009-03-01" @default.
- W2103353268 modified "2023-10-15" @default.
- W2103353268 title "The Role of CLCA Proteins in Inflammatory Airway Disease" @default.
- W2103353268 cites W123164916 @default.
- W2103353268 cites W128447005 @default.
- W2103353268 cites W1483023618 @default.
- W2103353268 cites W1496572494 @default.
- W2103353268 cites W1497689831 @default.
- W2103353268 cites W1503059924 @default.
- W2103353268 cites W1522298610 @default.
- W2103353268 cites W1523218557 @default.
- W2103353268 cites W1555461214 @default.
- W2103353268 cites W1601141343 @default.
- W2103353268 cites W1807635121 @default.
- W2103353268 cites W1867284234 @default.
- W2103353268 cites W1905165811 @default.
- W2103353268 cites W1965713984 @default.
- W2103353268 cites W1966016238 @default.
- W2103353268 cites W1966032012 @default.
- W2103353268 cites W1972279565 @default.
- W2103353268 cites W1974064614 @default.
- W2103353268 cites W1977739016 @default.
- W2103353268 cites W1978554064 @default.
- W2103353268 cites W1982266446 @default.
- W2103353268 cites W1982352462 @default.
- W2103353268 cites W1982825824 @default.
- W2103353268 cites W1982938776 @default.
- W2103353268 cites W1985115424 @default.
- W2103353268 cites W1989150324 @default.
- W2103353268 cites W1989501142 @default.
- W2103353268 cites W1991648511 @default.
- W2103353268 cites W1999044108 @default.
- W2103353268 cites W2000045311 @default.
- W2103353268 cites W2001809983 @default.
- W2103353268 cites W2003425871 @default.
- W2103353268 cites W2017704759 @default.
- W2103353268 cites W2019609817 @default.
- W2103353268 cites W2031695399 @default.
- W2103353268 cites W2031972979 @default.
- W2103353268 cites W2033441411 @default.
- W2103353268 cites W2033490823 @default.
- W2103353268 cites W2034911186 @default.
- W2103353268 cites W2035216573 @default.
- W2103353268 cites W2036385023 @default.
- W2103353268 cites W2036491602 @default.
- W2103353268 cites W2036980247 @default.
- W2103353268 cites W2038764988 @default.
- W2103353268 cites W2040137524 @default.
- W2103353268 cites W2040522025 @default.
- W2103353268 cites W2046309270 @default.
- W2103353268 cites W2047012860 @default.
- W2103353268 cites W2047263108 @default.
- W2103353268 cites W2050286381 @default.
- W2103353268 cites W2051162009 @default.
- W2103353268 cites W2053082037 @default.
- W2103353268 cites W2054483361 @default.
- W2103353268 cites W2055043387 @default.
- W2103353268 cites W2059232582 @default.
- W2103353268 cites W2060178110 @default.
- W2103353268 cites W2061066511 @default.
- W2103353268 cites W2061808825 @default.
- W2103353268 cites W2065036063 @default.
- W2103353268 cites W2065232674 @default.
- W2103353268 cites W2065269897 @default.
- W2103353268 cites W2066984712 @default.
- W2103353268 cites W2067591381 @default.
- W2103353268 cites W2068362128 @default.
- W2103353268 cites W2068787265 @default.
- W2103353268 cites W2070998216 @default.
- W2103353268 cites W2071601995 @default.
- W2103353268 cites W2071763658 @default.
- W2103353268 cites W2072376737 @default.
- W2103353268 cites W2072782033 @default.
- W2103353268 cites W2073799618 @default.
- W2103353268 cites W2080803595 @default.
- W2103353268 cites W2081922745 @default.
- W2103353268 cites W2084536845 @default.
- W2103353268 cites W2085021685 @default.
- W2103353268 cites W2085622988 @default.
- W2103353268 cites W2089548892 @default.
- W2103353268 cites W2091361930 @default.
- W2103353268 cites W2091969321 @default.
- W2103353268 cites W2094395747 @default.
- W2103353268 cites W2096525273 @default.
- W2103353268 cites W2097820835 @default.
- W2103353268 cites W2097984707 @default.
- W2103353268 cites W2098834645 @default.
- W2103353268 cites W2100802471 @default.
- W2103353268 cites W2100940178 @default.
- W2103353268 cites W2101483843 @default.
- W2103353268 cites W2101612379 @default.
- W2103353268 cites W2103095881 @default.
- W2103353268 cites W2104244040 @default.