Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103360995> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2103360995 endingPage "M390" @default.
- W2103360995 startingPage "M385" @default.
- W2103360995 abstract "In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using event-related potentials (ERPs) was conducted.In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 +/- 1.7 yr; range 59-81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented.Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood.A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood." @default.
- W2103360995 created "2016-06-24" @default.
- W2103360995 creator A5040474066 @default.
- W2103360995 creator A5083695665 @default.
- W2103360995 creator A5084148049 @default.
- W2103360995 creator A5087691776 @default.
- W2103360995 date "1998-09-01" @default.
- W2103360995 modified "2023-10-11" @default.
- W2103360995 title "Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being" @default.
- W2103360995 doi "https://doi.org/10.1093/gerona/53a.5.m385" @default.
- W2103360995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9754145" @default.
- W2103360995 hasPublicationYear "1998" @default.
- W2103360995 type Work @default.
- W2103360995 sameAs 2103360995 @default.
- W2103360995 citedByCount "61" @default.
- W2103360995 countsByYear W21033609952012 @default.
- W2103360995 countsByYear W21033609952014 @default.
- W2103360995 countsByYear W21033609952015 @default.
- W2103360995 countsByYear W21033609952016 @default.
- W2103360995 countsByYear W21033609952018 @default.
- W2103360995 countsByYear W21033609952020 @default.
- W2103360995 countsByYear W21033609952021 @default.
- W2103360995 crossrefType "journal-article" @default.
- W2103360995 hasAuthorship W2103360995A5040474066 @default.
- W2103360995 hasAuthorship W2103360995A5083695665 @default.
- W2103360995 hasAuthorship W2103360995A5084148049 @default.
- W2103360995 hasAuthorship W2103360995A5087691776 @default.
- W2103360995 hasBestOaLocation W21033609951 @default.
- W2103360995 hasConcept C126322002 @default.
- W2103360995 hasConcept C134018914 @default.
- W2103360995 hasConcept C138496976 @default.
- W2103360995 hasConcept C142724271 @default.
- W2103360995 hasConcept C15744967 @default.
- W2103360995 hasConcept C169760540 @default.
- W2103360995 hasConcept C169900460 @default.
- W2103360995 hasConcept C204787440 @default.
- W2103360995 hasConcept C22334291 @default.
- W2103360995 hasConcept C27081682 @default.
- W2103360995 hasConcept C2776992908 @default.
- W2103360995 hasConcept C2777911890 @default.
- W2103360995 hasConcept C2780657110 @default.
- W2103360995 hasConcept C548259974 @default.
- W2103360995 hasConcept C67359045 @default.
- W2103360995 hasConcept C71315377 @default.
- W2103360995 hasConcept C71924100 @default.
- W2103360995 hasConcept C87813604 @default.
- W2103360995 hasConceptScore W2103360995C126322002 @default.
- W2103360995 hasConceptScore W2103360995C134018914 @default.
- W2103360995 hasConceptScore W2103360995C138496976 @default.
- W2103360995 hasConceptScore W2103360995C142724271 @default.
- W2103360995 hasConceptScore W2103360995C15744967 @default.
- W2103360995 hasConceptScore W2103360995C169760540 @default.
- W2103360995 hasConceptScore W2103360995C169900460 @default.
- W2103360995 hasConceptScore W2103360995C204787440 @default.
- W2103360995 hasConceptScore W2103360995C22334291 @default.
- W2103360995 hasConceptScore W2103360995C27081682 @default.
- W2103360995 hasConceptScore W2103360995C2776992908 @default.
- W2103360995 hasConceptScore W2103360995C2777911890 @default.
- W2103360995 hasConceptScore W2103360995C2780657110 @default.
- W2103360995 hasConceptScore W2103360995C548259974 @default.
- W2103360995 hasConceptScore W2103360995C67359045 @default.
- W2103360995 hasConceptScore W2103360995C71315377 @default.
- W2103360995 hasConceptScore W2103360995C71924100 @default.
- W2103360995 hasConceptScore W2103360995C87813604 @default.
- W2103360995 hasIssue "5" @default.
- W2103360995 hasLocation W21033609951 @default.
- W2103360995 hasLocation W21033609952 @default.
- W2103360995 hasOpenAccess W2103360995 @default.
- W2103360995 hasPrimaryLocation W21033609951 @default.
- W2103360995 hasRelatedWork W2013948416 @default.
- W2103360995 hasRelatedWork W2019690572 @default.
- W2103360995 hasRelatedWork W2036404189 @default.
- W2103360995 hasRelatedWork W2065631591 @default.
- W2103360995 hasRelatedWork W2067765841 @default.
- W2103360995 hasRelatedWork W2076624838 @default.
- W2103360995 hasRelatedWork W2080593020 @default.
- W2103360995 hasRelatedWork W2086288557 @default.
- W2103360995 hasRelatedWork W2103360995 @default.
- W2103360995 hasRelatedWork W4248197120 @default.
- W2103360995 hasVolume "53A" @default.
- W2103360995 isParatext "false" @default.
- W2103360995 isRetracted "false" @default.
- W2103360995 magId "2103360995" @default.
- W2103360995 workType "article" @default.