Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103370566> ?p ?o ?g. }
- W2103370566 endingPage "74" @default.
- W2103370566 startingPage "69" @default.
- W2103370566 abstract "Circadian rhythms in Drosophila are supported by a negative feedback loop, in which PERIOD (PER) and Timeless (TIM) shut down their own transcription as they translocate once a day from the cytoplasm of clock-containing cells to the nucleus. Period length is partially determined by an interval of cytoplasmic retention of the TIM and PER proteins. To study this process, we examined PER/TIM/Doubletime (DBT) physical interactions and nuclear translocation by imaging individual cultured Drosophila cells. Using live cell video microscopy and green fluorescent protein (GFP) tags, we observed dynamic patterns of stability and localization for DBT, PER, and TIM that resembled those previously found in vivo. These studies suggest that a cytoplasmic interval timer regulates nuclear translocation of these proteins. The cultured cell assay provides a potent system to study interactions among new and known genes involved in the generation of circadian behavior." @default.
- W2103370566 created "2016-06-24" @default.
- W2103370566 creator A5046474433 @default.
- W2103370566 creator A5049333462 @default.
- W2103370566 creator A5060991675 @default.
- W2103370566 date "2007-01-01" @default.
- W2103370566 modified "2023-09-27" @default.
- W2103370566 title "A PER/TIM/DBT Interval Timer for<i>Drosophila</i>'s Circadian Clock" @default.
- W2103370566 cites W1515229825 @default.
- W2103370566 cites W1530371171 @default.
- W2103370566 cites W1579370260 @default.
- W2103370566 cites W1968410906 @default.
- W2103370566 cites W1970785480 @default.
- W2103370566 cites W1973776058 @default.
- W2103370566 cites W1975635900 @default.
- W2103370566 cites W1992138479 @default.
- W2103370566 cites W1992749367 @default.
- W2103370566 cites W1995139743 @default.
- W2103370566 cites W2003045753 @default.
- W2103370566 cites W2005174604 @default.
- W2103370566 cites W2009135996 @default.
- W2103370566 cites W2014082672 @default.
- W2103370566 cites W2022398889 @default.
- W2103370566 cites W2023325911 @default.
- W2103370566 cites W2028678199 @default.
- W2103370566 cites W2030063045 @default.
- W2103370566 cites W2030478984 @default.
- W2103370566 cites W2040297364 @default.
- W2103370566 cites W2040561723 @default.
- W2103370566 cites W2040617029 @default.
- W2103370566 cites W2045982987 @default.
- W2103370566 cites W2056393772 @default.
- W2103370566 cites W2059288996 @default.
- W2103370566 cites W2060138058 @default.
- W2103370566 cites W2064550220 @default.
- W2103370566 cites W2065646286 @default.
- W2103370566 cites W2065793682 @default.
- W2103370566 cites W2070672002 @default.
- W2103370566 cites W2073036589 @default.
- W2103370566 cites W2087619545 @default.
- W2103370566 cites W2091953892 @default.
- W2103370566 cites W2094517427 @default.
- W2103370566 cites W2101386389 @default.
- W2103370566 cites W2113578944 @default.
- W2103370566 cites W2130515385 @default.
- W2103370566 cites W2133998474 @default.
- W2103370566 cites W2151305846 @default.
- W2103370566 cites W2156462826 @default.
- W2103370566 cites W2162754674 @default.
- W2103370566 cites W2168037738 @default.
- W2103370566 cites W2172206060 @default.
- W2103370566 cites W2346964101 @default.
- W2103370566 doi "https://doi.org/10.1101/sqb.2007.72.034" @default.
- W2103370566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18419263" @default.
- W2103370566 hasPublicationYear "2007" @default.
- W2103370566 type Work @default.
- W2103370566 sameAs 2103370566 @default.
- W2103370566 citedByCount "18" @default.
- W2103370566 countsByYear W21033705662012 @default.
- W2103370566 countsByYear W21033705662014 @default.
- W2103370566 countsByYear W21033705662015 @default.
- W2103370566 countsByYear W21033705662018 @default.
- W2103370566 countsByYear W21033705662019 @default.
- W2103370566 countsByYear W21033705662021 @default.
- W2103370566 crossrefType "journal-article" @default.
- W2103370566 hasAuthorship W2103370566A5046474433 @default.
- W2103370566 hasAuthorship W2103370566A5049333462 @default.
- W2103370566 hasAuthorship W2103370566A5060991675 @default.
- W2103370566 hasBestOaLocation W21033705661 @default.
- W2103370566 hasConcept C104317684 @default.
- W2103370566 hasConcept C121332964 @default.
- W2103370566 hasConcept C121446783 @default.
- W2103370566 hasConcept C138626823 @default.
- W2103370566 hasConcept C142613039 @default.
- W2103370566 hasConcept C1491633281 @default.
- W2103370566 hasConcept C153911025 @default.
- W2103370566 hasConcept C15526883 @default.
- W2103370566 hasConcept C169760540 @default.
- W2103370566 hasConcept C173018170 @default.
- W2103370566 hasConcept C190062978 @default.
- W2103370566 hasConcept C24890656 @default.
- W2103370566 hasConcept C2776041557 @default.
- W2103370566 hasConcept C2776633867 @default.
- W2103370566 hasConcept C2778880379 @default.
- W2103370566 hasConcept C2780723820 @default.
- W2103370566 hasConcept C2781291010 @default.
- W2103370566 hasConcept C38606739 @default.
- W2103370566 hasConcept C41008148 @default.
- W2103370566 hasConcept C54355233 @default.
- W2103370566 hasConcept C86803240 @default.
- W2103370566 hasConcept C9390403 @default.
- W2103370566 hasConcept C95444343 @default.
- W2103370566 hasConceptScore W2103370566C104317684 @default.
- W2103370566 hasConceptScore W2103370566C121332964 @default.
- W2103370566 hasConceptScore W2103370566C121446783 @default.
- W2103370566 hasConceptScore W2103370566C138626823 @default.
- W2103370566 hasConceptScore W2103370566C142613039 @default.
- W2103370566 hasConceptScore W2103370566C1491633281 @default.