FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103372704> ?p ?o ?g. }

• W2103372704 endingPage "600" @default.
• W2103372704 startingPage "592" @default.
• W2103372704 abstract "An outbreak of infectious bursal disease (IBD) in two California layer flocks resulted in the isolation of two infectious bursal disease viruses designated rA and rB. Increased mortality plus gross and histopathology in the layer flocks suggested rA and rB could be very virulent infectious bursal disease virus (vvIBDV). Preliminary studies indicated that high mortality resulted when bursa homogenates from the layer farms were used to inoculate specific-pathogen-free (SPF) chicks. In addition, rA and rB contained VP2 amino acid sequences typically seen in vvIBDV. Molecular and in vivo studies were conducted to more thoroughly identify and characterize the rA and rB viruses. Nucleotide sequence analysis demonstrated that rA and rB had identical sequences across the hypervariable VP2 (hvVP2) and segment B regions examined, and their amino acid sequences in the hvVP2 region were identical to the vvIBDV type strains UK 661, OKYM, and Harbin. Furthermore, the genome segment B nucleotide sequences examined for rA and rB were a 98.1% match with vvIBDV and only an 88.0% match with classic IBDV strains. Phylogenetic analysis placed the rA and rB viruses with other vvIBDV and confirmed these viruses were close genetic descendants of vvIBDV seen around the world. Pathogenicity studies in 4-wk-old SPF chicks demonstrated that at a high dose (105.5 50% egg infective dose [EID50]) and a low dose (102.0 EID50) of rA and rB, mortality ranged from 91% to 100%. A pathogenic classic virus, standard challenge (STC), at similar doses did not cause mortality in the SPF chicks. In addition, mortality occurred in three out of four SPF birds exposed by direct contact to rA and rB inoculated chicks. Serum from convalescent birds inoculated with rA had high titers to IBDV but were negative for antibodies to infectious bronchitis virus, avian influenza virus, chicken anemia virus, Newcastle disease virus, Mycoplasma gallisepticum, and Mycoplasma synoviae. Virus isolation attempts on the rA and rB bursa homogenate inocula also indicated that no contaminating microorganisms contributed to the high mortality and pathology observed in the SPF chicks. In one experiment, broilers with maternal immunity to IBDV were protected from infection and disease when they were challenged with 102 EID50 and 105 EID50 of the STC virus. When challenged with 102 EID50 of the rA virus, the maternally immune broilers were protected from disease but not infection as evidenced by a positive reverse transcription–polymerase chain reaction (RT-PCR) assay for the virus. When the broilers were challenged with 105 EID50 of the rA virus, they had typical gross and histopathologic signs of IBD but no mortality by 7 days postinoculation. It was concluded that the rA and rB viruses meet the genotypic and phenotypic characteristics of a vvIBDV." @default.
• W2103372704 created "2016-06-24" @default.
• W2103372704 creator A5000405641 @default.
• W2103372704 creator A5044822612 @default.
• W2103372704 creator A5049802396 @default.
• W2103372704 creator A5066306706 @default.
• W2103372704 creator A5077550130 @default.
• W2103372704 creator A5082210119 @default.
• W2103372704 creator A5089157924 @default.
• W2103372704 date "2009-12-01" @default.
• W2103372704 modified "2023-10-10" @default.
• W2103372704 title "Characteristics of a Very Virulent Infectious Bursal Disease Virus from California" @default.
• W2103372704 cites W1983805470 @default.
• W2103372704 cites W1992761802 @default.
• W2103372704 cites W1993714306 @default.
• W2103372704 cites W2016681935 @default.
• W2103372704 cites W2035803121 @default.
• W2103372704 cites W2045871663 @default.
• W2103372704 cites W2045954345 @default.
• W2103372704 cites W2061950855 @default.
• W2103372704 cites W2067797400 @default.
• W2103372704 cites W2074462158 @default.
• W2103372704 cites W2094324730 @default.
• W2103372704 cites W2112278655 @default.
• W2103372704 cites W2113044929 @default.
• W2103372704 cites W2146396346 @default.
• W2103372704 cites W2154430305 @default.
• W2103372704 cites W2162405783 @default.
• W2103372704 cites W2174415040 @default.
• W2103372704 cites W2183207384 @default.
• W2103372704 cites W2323179318 @default.
• W2103372704 cites W2324521453 @default.
• W2103372704 doi "https://doi.org/10.1637/8957-061109-reg.1" @default.
• W2103372704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20095162" @default.
• W2103372704 hasPublicationYear "2009" @default.
• W2103372704 type Work @default.
• W2103372704 sameAs 2103372704 @default.
• W2103372704 citedByCount "34" @default.
• W2103372704 countsByYear W21033727042012 @default.
• W2103372704 countsByYear W21033727042013 @default.
• W2103372704 countsByYear W21033727042014 @default.
• W2103372704 countsByYear W21033727042015 @default.
• W2103372704 countsByYear W21033727042016 @default.
• W2103372704 countsByYear W21033727042017 @default.
• W2103372704 countsByYear W21033727042018 @default.
• W2103372704 countsByYear W21033727042019 @default.
• W2103372704 countsByYear W21033727042021 @default.
• W2103372704 countsByYear W21033727042022 @default.
• W2103372704 countsByYear W21033727042023 @default.
• W2103372704 crossrefType "journal-article" @default.
• W2103372704 hasAuthorship W2103372704A5000405641 @default.
• W2103372704 hasAuthorship W2103372704A5044822612 @default.
• W2103372704 hasAuthorship W2103372704A5049802396 @default.
• W2103372704 hasAuthorship W2103372704A5066306706 @default.
• W2103372704 hasAuthorship W2103372704A5077550130 @default.
• W2103372704 hasAuthorship W2103372704A5082210119 @default.
• W2103372704 hasAuthorship W2103372704A5089157924 @default.
• W2103372704 hasConcept C104317684 @default.
• W2103372704 hasConcept C116675565 @default.
• W2103372704 hasConcept C134215735 @default.
• W2103372704 hasConcept C151730666 @default.
• W2103372704 hasConcept C159047783 @default.
• W2103372704 hasConcept C159654299 @default.
• W2103372704 hasConcept C193252679 @default.
• W2103372704 hasConcept C2522874641 @default.
• W2103372704 hasConcept C2777810641 @default.
• W2103372704 hasConcept C54355233 @default.
• W2103372704 hasConcept C60987743 @default.
• W2103372704 hasConcept C81566733 @default.
• W2103372704 hasConcept C86803240 @default.
• W2103372704 hasConceptScore W2103372704C104317684 @default.
• W2103372704 hasConceptScore W2103372704C116675565 @default.
• W2103372704 hasConceptScore W2103372704C134215735 @default.
• W2103372704 hasConceptScore W2103372704C151730666 @default.
• W2103372704 hasConceptScore W2103372704C159047783 @default.
• W2103372704 hasConceptScore W2103372704C159654299 @default.
• W2103372704 hasConceptScore W2103372704C193252679 @default.
• W2103372704 hasConceptScore W2103372704C2522874641 @default.
• W2103372704 hasConceptScore W2103372704C2777810641 @default.
• W2103372704 hasConceptScore W2103372704C54355233 @default.
• W2103372704 hasConceptScore W2103372704C60987743 @default.
• W2103372704 hasConceptScore W2103372704C81566733 @default.
• W2103372704 hasConceptScore W2103372704C86803240 @default.
• W2103372704 hasIssue "4" @default.
• W2103372704 hasLocation W21033727041 @default.
• W2103372704 hasLocation W21033727042 @default.
• W2103372704 hasOpenAccess W2103372704 @default.
• W2103372704 hasPrimaryLocation W21033727041 @default.
• W2103372704 hasRelatedWork W1963883483 @default.
• W2103372704 hasRelatedWork W1965958885 @default.
• W2103372704 hasRelatedWork W2067484826 @default.
• W2103372704 hasRelatedWork W2100837761 @default.
• W2103372704 hasRelatedWork W2107230345 @default.
• W2103372704 hasRelatedWork W2108115336 @default.
• W2103372704 hasRelatedWork W2261775465 @default.
• W2103372704 hasRelatedWork W2417773420 @default.
• W2103372704 hasRelatedWork W2982791591 @default.
• W2103372704 hasRelatedWork W4288008926 @default.

• next