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- W2103375140 endingPage "R17" @default.
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- W2103375140 abstract "We present GraphProt, a computational framework for learning sequence- and structure-binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental data. We benchmark GraphProt, demonstrating that the modeled binding preferences conform to the literature, and showcase the biological relevance and two applications of GraphProt models. First, estimated binding affinities correlate with experimental measurements. Second, predicted Ago2 targets display higher levels of expression upon Ago2 knockdown, whereas control targets do not. Computational binding models, such as those provided by GraphProt, are essential for predicting RBP binding sites and affinities in all tissues. GraphProt is freely available at http://www.bioinf.uni-freiburg.de/Software/GraphProt ." @default.
- W2103375140 created "2016-06-24" @default.
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- W2103375140 date "2014-01-01" @default.
- W2103375140 modified "2023-10-18" @default.
- W2103375140 title "GraphProt: modeling binding preferences of RNA-binding proteins" @default.
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- W2103375140 doi "https://doi.org/10.1186/gb-2014-15-1-r17" @default.
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