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• W2103386635 abstract "Significance Women with high-grade serous ovarian cancer (HGSC) harboring Cyclin E1 ( CCNE1 ) gene amplification generally face a poor clinical outcome. These tumors comprise a significant group of ∼20% of HGSCs that are not associated with BRCA1/2 mutation and are unlikely to respond to standard cytotoxic or poly-ADP-ribose polymerase inhibitors. We identified a specific dependency on BRCA1 and members of the ubiquitin pathway in CCNE1 -amplified tumors. The requirement for BRCA1 seems to account for the mutual exclusivity of mutations observed in primary tumors. We propose a unique therapeutic strategy involving inhibition of the proteasome and homologous recombination function with bortezomib. Our findings are likely to have relevance to the treatment of other tumor types with CCNE1 amplification, including triple negative breast cancer." @default.
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• W2103386635 date "2013-11-11" @default.
• W2103386635 modified "2023-10-10" @default.
• W2103386635 title "Synthetic lethality between <i>CCNE1</i> amplification and loss of <i>BRCA1</i>" @default.
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• W2103386635 doi "https://doi.org/10.1073/pnas.1314302110" @default.
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