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• W2103387619 startingPage "2887" @default.
• W2103387619 abstract "The enzymatic activity of filamentous dephosphorylated smooth muscle myosin has been difficult to determine because the polymer disassembles to the folded conformation in the presence of MgATP. Monoclonal antirod antibodies were used here to fix dephosphorylated myosin in the filamentous state. The steady-state actin-activated ATPase of phosphorylated filaments was 30-100-fold higher than that of antibody-stabilized dephosphorylated filaments, suggesting that phosphorylation can activate ATPase activity independent of changes in assembly. The degree of regulation may exceed 100-fold, because steady-state measurements slightly overestimate the rate of product release from dephosphorylated filaments. Single-turnover experiments in the absence of actin showed that although dephosphorylated folded myosin released products at the low rate of 0.0005 s-1 (Cross, R. A., K. E. Cross, A. Sobieszek. 1986. EMBO [Eur. Mol. Biol. Organ.] J. 5:2637-2641) the rate of product release from dephosphorylated filaments was only 3-12-fold higher, depending on the ionic strength. The addition of actin did not increase this rate to any appreciable extent. Dephosphorylated filaments and dephosphorylated heavy meromyosin (Sellers, J. R. 1985. J. Biol. Chem. 260:15815-15819) thus have similar low rates of phosphate release both in the presence and absence of actin. These results show that light chain phosphorylation alone, without invoking other mechanisms, is an effective switch for regulating the activity of smooth muscle myosin filaments." @default.
• W2103387619 created "2016-06-24" @default.
• W2103387619 creator A5035579449 @default.
• W2103387619 date "1989-12-01" @default.
• W2103387619 modified "2023-09-26" @default.
• W2103387619 title "Filamentous smooth muscle myosin is regulated by phosphorylation." @default.
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• W2103387619 doi "https://doi.org/10.1083/jcb.109.6.2887" @default.
• W2103387619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2115938" @default.
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