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- W2103428657 abstract "Mice made dependent on morphine using slow-release morphine pellets for 96 h were withdrawn by removal of pellets, followed by a sublethal dose of LPS 24 h later. These animals exhibited 100% lethality. Animals withdrawn from placebo pellets receiving LPS all survived, as did morphine-withdrawn mice receiving saline. Morphine-withdrawn LPS-treated animals had elevated serum TNF-α and nitric oxide levels, and depressed IL-12 levels compared to controls. Anti-TNF-α antibody given prior to LPS challenge afforded significant protection to morphine-withdrawn animals. These studies show that morphine withdrawal sensitizes to LPS lethality via increased production of TNF-α." @default.
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- W2103428657 date "2005-07-01" @default.
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- W2103428657 title "Morphine withdrawal sensitizes mice to lipopolysaccharide: Elevated TNF-α and nitric oxide with decreased IL-12" @default.
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- W2103428657 doi "https://doi.org/10.1016/j.jneuroim.2005.03.017" @default.
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