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• W2103441105 abstract "Sudden cardiac death (SCD) is one of the main causes of cardiac death. There are two main strategies to prevent it: managing cardiovascular risk factors and reducing the risk of ventricular arrhythmias. Implantable cardiac defibrillators (ICDs) constitute the standard therapy for both primary and secondary prevention; however, they are not widely available in settings with limited resources. The antiarrhythmic amiodarone has been proposed as an alternative to ICD.To evaluate the effectiveness of amiodarone for primary or secondary prevention in SCD compared with placebo or no intervention or any other antiarrhythmic drugs in participants at high risk (primary prevention) or who have recovered from a cardiac arrest or a syncope due to Ventricular Tachycardia/Ventricular Fibrillation, or VT/VF (secondary prevention).We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (OVID), EMBASE (OVID), CINAHL (EBSCO) and LILACS on 26 March 2015. We reviewed reference lists of included studies and selected reviews on the topic, contacted authors of included studies, screened relevant meetings and searched in registers for ongoing trials. We applied no language restrictions.Randomised and quasi-randomised trials assessing the efficacy of amiodarone versus placebo, no intervention, or other antiarrhythmics in adults. For primary prevention we considered participants at high risk for SCD. For secondary prevention we considered participants recovered from cardiac arrest or syncope due to ventricular arrhythmias.Two authors independently assessed the trials for inclusion and extracted relevant data. We contacted trial authors for missing data. We performed meta-analyses using a random-effects model. We calculated risk ratios (RR) for dichotomous outcomes with 95% confidence intervals (CIs). Three studies included more than one comparison.We included 24 studies (9,997 participants). Seventeen studies evaluated amiodarone for primary prevention and six for secondary prevention. Only three studies used an ICD concomitantly with amiodarone for the comparison (all of them for secondary prevention).For primary prevention, amiodarone compared to placebo or no intervention (17 studies, 8383 participants) reduced SCD (RR 0.76; 95% CI 0.66 to 0.88), cardiac mortality (RR 0.86; 95% CI 0.77 to 0.96) and all-cause mortality (RR 0.88; 95% CI 0.78 to 1.00). The quality of the evidence was low.Compared to other antiarrhythmics (three studies, 540 participants), amiodarone reduced SCD (RR 0.44; 95% CI 0.19 to 1.00), cardiac mortality (RR 0.41; 95% CI 0.20 to 0.86) and all-cause mortality (RR 0.37; 95% CI 0.18 to 0.76). The quality of the evidence was moderate.For secondary prevention, amiodarone compared to placebo or no intervention (two studies, 440 participants) appeared to increase the risk of SCD (RR 4.32; 95% CI 0.87 to 21.49) and all-cause mortality (RR 3.05; 1.33 to 7.01). However, the quality of the evidence was very low. Compared to other antiarrhythmics (four studies, 839 participants) amiodarone appeared to increase the risk of SCD (RR 1.40; 95% CI 0.56 to 3.52; very low quality of evidence), but there was no effect in all-cause mortality (RR 1.03; 95% CI 0.75 to 1.42; low quality evidence).Amiodarone was associated with an increase in pulmonary and thyroid adverse events.There is low to moderate quality evidence that amiodarone reduces SCD, cardiac and all-cause mortality when compared to placebo or no intervention for primary prevention, and its effects are superior to other antiarrhythmics.It is uncertain if amiodarone reduces or increases SCD and mortality for secondary prevention because the quality of the evidence was very low." @default.
• W2103441105 created "2016-06-24" @default.
• W2103441105 creator A5002641708 @default.
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• W2103441105 creator A5040036979 @default.
• W2103441105 creator A5062467340 @default.
• W2103441105 creator A5089834513 @default.
• W2103441105 date "2015-12-08" @default.
• W2103441105 modified "2023-10-17" @default.
• W2103441105 title "Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death" @default.
• W2103441105 cites W1841210729 @default.
• W2103441105 cites W1964545791 @default.
• W2103441105 cites W1965400992 @default.
• W2103441105 cites W1966953116 @default.
• W2103441105 cites W1968552092 @default.
• W2103441105 cites W1969133644 @default.
• W2103441105 cites W1973016351 @default.
• W2103441105 cites W1976999667 @default.
• W2103441105 cites W1978683847 @default.
• W2103441105 cites W1982973712 @default.
• W2103441105 cites W1983107066 @default.
• W2103441105 cites W1987444265 @default.
• W2103441105 cites W1987903405 @default.
• W2103441105 cites W1995080987 @default.
• W2103441105 cites W1995799061 @default.
• W2103441105 cites W2010143907 @default.
• W2103441105 cites W2010447306 @default.
• W2103441105 cites W2010802531 @default.
• W2103441105 cites W2016791393 @default.
• W2103441105 cites W2016927077 @default.
• W2103441105 cites W2017432897 @default.
• W2103441105 cites W2019820914 @default.
• W2103441105 cites W2023906304 @default.
• W2103441105 cites W2024269966 @default.
• W2103441105 cites W2025474211 @default.
• W2103441105 cites W2026225505 @default.
• W2103441105 cites W2030053251 @default.
• W2103441105 cites W2035581854 @default.
• W2103441105 cites W2039244426 @default.
• W2103441105 cites W2046147094 @default.
• W2103441105 cites W2046163335 @default.
• W2103441105 cites W2050512195 @default.
• W2103441105 cites W2052059329 @default.
• W2103441105 cites W2053307706 @default.
• W2103441105 cites W2054379114 @default.
• W2103441105 cites W2054732743 @default.
• W2103441105 cites W2056472288 @default.
• W2103441105 cites W2065032329 @default.
• W2103441105 cites W2066789391 @default.
• W2103441105 cites W2067152768 @default.
• W2103441105 cites W2068333512 @default.
• W2103441105 cites W2070397684 @default.
• W2103441105 cites W2070583202 @default.
• W2103441105 cites W2073991158 @default.
• W2103441105 cites W2075142560 @default.
• W2103441105 cites W2075175982 @default.
• W2103441105 cites W2084892644 @default.
• W2103441105 cites W2099236415 @default.
• W2103441105 cites W2103441105 @default.
• W2103441105 cites W2107428340 @default.
• W2103441105 cites W2109740912 @default.
• W2103441105 cites W2110701325 @default.
• W2103441105 cites W2112829244 @default.
• W2103441105 cites W2114270660 @default.
• W2103441105 cites W2114316938 @default.
• W2103441105 cites W2117271182 @default.
• W2103441105 cites W2119818163 @default.
• W2103441105 cites W2120628509 @default.
• W2103441105 cites W2121221780 @default.
• W2103441105 cites W2125174148 @default.
• W2103441105 cites W2135456762 @default.
• W2103441105 cites W2139637015 @default.
• W2103441105 cites W2142006493 @default.
• W2103441105 cites W2143518969 @default.
• W2103441105 cites W2143923202 @default.
• W2103441105 cites W2144131521 @default.
• W2103441105 cites W2146962564 @default.
• W2103441105 cites W2153830557 @default.
• W2103441105 cites W2166633479 @default.
• W2103441105 cites W2167443474 @default.
• W2103441105 cites W2172282913 @default.
• W2103441105 cites W22184475 @default.
• W2103441105 cites W2238576904 @default.
• W2103441105 cites W2262313369 @default.
• W2103441105 cites W2269745365 @default.
• W2103441105 cites W2273078845 @default.
• W2103441105 cites W2292499820 @default.
• W2103441105 cites W2314139393 @default.
• W2103441105 cites W2323551008 @default.
• W2103441105 cites W2331955367 @default.
• W2103441105 cites W2332287011 @default.
• W2103441105 cites W2341968681 @default.
• W2103441105 cites W2405096410 @default.
• W2103441105 cites W2407787164 @default.
• W2103441105 cites W2407847045 @default.
• W2103441105 cites W2409024095 @default.
• W2103441105 cites W2409338872 @default.
• W2103441105 cites W2409819300 @default.
• W2103441105 cites W2411441212 @default.

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