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• W2103442867 abstract "The dexamethasone suppression test (DST), frequently abnormal in mood disorder patients, is considered to measure glucocorticoid receptor-mediated negative feedback. We examined the hypothesis that the, apparently more sensitive, dexamethasone/corticotrophin-releasing-hormone (dex/CRH) test unveils subtle hypothalamic–pituitary–adrenal axis disturbance not detected by the DST in 82 patients with mood disorders and 28 controls. There was a close correlation between the cortisol responses on the two tests (rs=0.73, p<0.0005). However, ROC analysis revealed that the dex/CRH test had better diagnostic performance than the DST (p=0.031). The sensitivity of delta cortisol (from the dex/CRH) was 61.9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility." @default.
• W2103442867 created "2016-06-24" @default.
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• W2103442867 date "2006-08-01" @default.
• W2103442867 modified "2023-09-25" @default.
• W2103442867 title "The dex/CRH test—Is it better than the DST?" @default.
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• W2103442867 doi "https://doi.org/10.1016/j.psyneuen.2006.03.001" @default.
• W2103442867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16701957" @default.
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