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- W2103444446 abstract "Purpose Quilty lesions have controversial associations with acute cellular rejection(ACR), mostly causing confusion in diagnosis. Recent molecular profiling in cardiac transplants has suggested that Quilty lesions are more closely associated with poor left ventricular function (LVEF) and transcripts of inflammation and microvascular injury rather than with ACR. We sought to examine the relationship of Quilty lesions and antibody-mediated rejection (pAMR) and the relationship of these findings to death from cardiovascular (CV) causes. Methods and Materials The UTAH Cardiac Transplant Pathology Database was used for this analysis. Biopsy results capture Quilty independently. Outcome parameters are also captured. We correlated the presence of Quilty lesions with pAMR (grades 1 to 3) and death from CV causes or retransplant over the life of the database (1985-2012). Cox proportional hazard modeling was done to evaluate the results. Results 999 heart transplant recipients with 13,155 biopsies were studied. In patients with 3 biopsies showing pAMR (3xpAMR) in the first year, there was a significant correlation with Quilty on one biopsy compared to patients without 3 x pAMR (p= figure 1 ] Conclusions There is a higher risk of CV associated death related to the presence of Quilty lesions in biopsies from patients with pAMR. Furthermore, this study defines a clear relationship between pAMR and Quilty, supporting the molecular evidence that Quilty is a marker of inflammatory and injury transcripts in cardiac transplantation." @default.
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- W2103444446 date "2013-04-01" @default.
- W2103444446 modified "2023-10-18" @default.
- W2103444446 title "Quilty Revisited: Association with pAMR and Worse Outcomes Post Heart Transplantation" @default.
- W2103444446 doi "https://doi.org/10.1016/j.healun.2013.01.1019" @default.
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