FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103445478> ?p ?o ?g. }

• W2103445478 endingPage "1202" @default.
• W2103445478 startingPage "1193" @default.
• W2103445478 abstract "We have analyzed transgenic mice carrying versions of a human T cell receptor (TCR)-δ gene minilocus to study the developmental control of VDJ (variable/diversity/joining) recombination. Previous data indicated that a 1.4-kb DNA fragment carrying the TCR-δ enhancer (Eδ) efficiently activates minilocus VDJ recombination in vivo. We tested whether the transcription factor CBF/PEBP2 plays an important role in the ability of Eδ to activate VDJ recombination by analyzing VDJ recombination in mice carrying a minilocus in which the δE3 element of Eδ includes a mutated CBF/PEBP2 binding site. The enhancer-dependent VD to J step of minilocus rearrangement was dramatically inhibited in three of four transgenic lines, arguing that the binding of CBF/PEBP2 plays a role in modulating local accessibility to the VDJ recombinase in vivo. Because mutation of the δE3 binding site for the transcription factor c-Myb had previously established a similar role for c-Myb, and because a 60-bp fragment of Eδ carrying δE3 and δE4 binding sites for CBF/PEBP2, c-Myb, and GATA-3 displays significant enhancer activity in transient transfection experiments, we tested whether this fragment of Eδ is sufficient to activate VDJ recombination in vivo. This fragment failed to efficiently activate the enhancerdependent VD to J step of minilocus rearrangement in all three transgenic lines examined, indicating that the binding of CBF/PEBP2 and c-Myb to their cognate sites within Eδ, although necessary, is not sufficient for the activation of VDJ recombination by Eδ. These results imply that CBF/PEBP2 and c-Myb collaborate with additional factors that bind elsewhere within Eδ to modulate local accessibility to the VDJ recombinase in vivo." @default.
• W2103445478 created "2016-06-24" @default.
• W2103445478 creator A5011304020 @default.
• W2103445478 creator A5048430317 @default.
• W2103445478 creator A5075092692 @default.
• W2103445478 creator A5088455217 @default.
• W2103445478 date "1997-04-07" @default.
• W2103445478 modified "2023-10-16" @default.
• W2103445478 title "Regulation of T Cell Receptor δ Gene Rearrangement by CBF/PEBP2" @default.
• W2103445478 cites W125903238 @default.
• W2103445478 cites W138134223 @default.
• W2103445478 cites W1486439009 @default.
• W2103445478 cites W1598468393 @default.
• W2103445478 cites W1599176230 @default.
• W2103445478 cites W1599334221 @default.
• W2103445478 cites W169978917 @default.
• W2103445478 cites W1732505601 @default.
• W2103445478 cites W1750508301 @default.
• W2103445478 cites W1867259879 @default.
• W2103445478 cites W1875148047 @default.
• W2103445478 cites W1890296098 @default.
• W2103445478 cites W1926039203 @default.
• W2103445478 cites W1946913806 @default.
• W2103445478 cites W1970139633 @default.
• W2103445478 cites W1990974448 @default.
• W2103445478 cites W2003455359 @default.
• W2103445478 cites W2003514328 @default.
• W2103445478 cites W2003617876 @default.
• W2103445478 cites W2006461546 @default.
• W2103445478 cites W2024208188 @default.
• W2103445478 cites W2032960386 @default.
• W2103445478 cites W2038589622 @default.
• W2103445478 cites W2056560239 @default.
• W2103445478 cites W2058585577 @default.
• W2103445478 cites W2060913542 @default.
• W2103445478 cites W2063330602 @default.
• W2103445478 cites W2064740655 @default.
• W2103445478 cites W2065985580 @default.
• W2103445478 cites W2066913325 @default.
• W2103445478 cites W2067016089 @default.
• W2103445478 cites W2073219326 @default.
• W2103445478 cites W2085033687 @default.
• W2103445478 cites W2089269522 @default.
• W2103445478 cites W2093468443 @default.
• W2103445478 cites W2097673590 @default.
• W2103445478 cites W2109943424 @default.
• W2103445478 cites W2119971154 @default.
• W2103445478 cites W2119973182 @default.
• W2103445478 cites W2121799773 @default.
• W2103445478 cites W2124597426 @default.
• W2103445478 cites W2125852599 @default.
• W2103445478 cites W2130002948 @default.
• W2103445478 cites W2133010718 @default.
• W2103445478 cites W2139711308 @default.
• W2103445478 cites W2139968053 @default.
• W2103445478 cites W2141947090 @default.
• W2103445478 cites W2142778960 @default.
• W2103445478 cites W2154029983 @default.
• W2103445478 cites W2157171800 @default.
• W2103445478 cites W2158610312 @default.
• W2103445478 cites W2159374958 @default.
• W2103445478 cites W2159422758 @default.
• W2103445478 cites W2173817007 @default.
• W2103445478 cites W2258207141 @default.
• W2103445478 cites W2401367987 @default.
• W2103445478 cites W2404041716 @default.
• W2103445478 cites W2418737438 @default.
• W2103445478 cites W4246441622 @default.
• W2103445478 cites W4250625694 @default.
• W2103445478 cites W4255146022 @default.
• W2103445478 doi "https://doi.org/10.1084/jem.185.7.1193" @default.
• W2103445478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2196263" @default.
• W2103445478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9104806" @default.
• W2103445478 hasPublicationYear "1997" @default.
• W2103445478 type Work @default.
• W2103445478 sameAs 2103445478 @default.
• W2103445478 citedByCount "38" @default.
• W2103445478 countsByYear W21034454782013 @default.
• W2103445478 countsByYear W21034454782014 @default.
• W2103445478 countsByYear W21034454782015 @default.
• W2103445478 countsByYear W21034454782016 @default.
• W2103445478 countsByYear W21034454782019 @default.
• W2103445478 countsByYear W21034454782020 @default.
• W2103445478 countsByYear W21034454782022 @default.
• W2103445478 crossrefType "journal-article" @default.
• W2103445478 hasAuthorship W2103445478A5011304020 @default.
• W2103445478 hasAuthorship W2103445478A5048430317 @default.
• W2103445478 hasAuthorship W2103445478A5075092692 @default.
• W2103445478 hasAuthorship W2103445478A5088455217 @default.
• W2103445478 hasBestOaLocation W21034454781 @default.
• W2103445478 hasConcept C102230213 @default.
• W2103445478 hasConcept C102414288 @default.
• W2103445478 hasConcept C104317684 @default.
• W2103445478 hasConcept C111936080 @default.
• W2103445478 hasConcept C113646796 @default.
• W2103445478 hasConcept C153911025 @default.
• W2103445478 hasConcept C156695909 @default.
• W2103445478 hasConcept C2992511266 @default.

• next