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• W2103445752 abstract "Cord blood is an alternative stem cell source for patients, but single cord blood units (CBU) may not contain sufficient cell dose for cord blood transplantation of adults. Double cord blood transplantation (DCBT) has been used to increase the cell dose, but the majority of reported patients have been Caucasian. We conducted a retrospective analysis of 43 consecutive DCBT recipients who received at least one cord blood unit from the StemCyte cord blood banks. The median age was 21 years (range 1-59) and the median weight was 59 kg (range 11-112). Diagnoses were: 14 AML, 9 ALL, 6 CML, 5 Thalassemia, 2 Myelodysplasia, 1 lymphoma, 1 aplastic anemia and 5 others. 54% were advanced risk, 26% standard risk, and 20% unknown risk status for the leukemia/ lymphoma/MDS cases. Sixty seven percent of the recipients were non-Caucasian—15 patients were Asian, 14 Caucasian, 4 Native American, 3 Hispanic, 3 African American, 1 mixed race and 3 unknown. Patients were treated with a variety of conditioning regimens (28% reduced intensity) at 21 international centers over 4 continents. 19 patients received 2 plasma depleted cord blood units. Cord unit characteristics were as follows: median pre-freeze TNC dose 3.4 × 107/kg, median pre-freeze CD34 dose 1.1 × 105/kg. The median time to neutrophil (ANC500) engraftment was 22 days and the median time to platelet 20K and 50K engraftment were 45 days and 62 days respectively. Kaplan-Meier estimates of 1-year transplant related mortality, overall survival, and disease free survival were 37%, 49%, and 44 % respectively. Causes of death include infection (33%), multi-organ failure (21%), relapse (17%), GvHD (0%), and other (29%). Engraftment correlated with cell dose and disease risk status in univariate analysis. In conclusion, 1) Double cord blood transplantation can be performed effectively in a racially diverse patient population, 2) Plasma depleted cord blood units can be used safely, 3) Cell counts remain important for engraftment even with the use of 2 cord blood units.Tabled 1Outcome Summary of PD DCBTANC500 EngraftmentPlt 20KPlt 50K1-Yr Relapse100 day & 1-Yr TRM1-Yr OS1-Yr DFSProbability, median time (range)86±6%, 22 days (11-47)76±11%, 45 days (29-146)77±11%, 62 days (38-148)29±9%26±7%, 37±8%49±8%44±8% Open table in a new tab" @default.
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• W2103445752 date "2007-02-01" @default.
• W2103445752 modified "2023-10-16" @default.
• W2103445752 title "336: Outcomes of double cord blood transplantation (DCBT) in a diverse population" @default.
• W2103445752 doi "https://doi.org/10.1016/j.bbmt.2006.12.341" @default.
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