Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103445961> ?p ?o ?g. }
- W2103445961 endingPage "1476" @default.
- W2103445961 startingPage "1466" @default.
- W2103445961 abstract "Abstract Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulated in colorectal cancer. This study was aimed to investigate the etiopathogenic role of AKR1B10 in ulcerative colitis and CAC. Experimental Design: Ulcerative colitis and CAC biopsies (paraffin-embedded sections) and frozen tissues were collected to examine AKR1B10 expression. Aldo-keto reductase 1B8 (the ortholog of human AKR1B10) knockout (AKR1B8−/−) mice were produced to estimate its role in the susceptibility and severity of chronic colitis and associated dysplastic lesions, induced by dextran sulfate sodium (DSS) at a low dose (2%). Genome-wide exome sequencing was used to profile DNA damage in DSS-induced colitis and tumors. Results: AKR1B10 expression was markedly diminished in over 90% of ulcerative colitis and CAC tissues. AKR1B8 deficiency led to reduced lipid synthesis from butyrate and diminished proliferation of colonic epithelial cells. The DSS-treated AKR1B8−/− mice demonstrated impaired injury repair of colonic epithelium and more severe bleeding, inflammation, and ulceration. These AKR1B8−/− mice had more severe oxidative stress and DNA damage, and dysplasias were more frequent and at a higher grade in the AKR1B8−/− mice than in wild-type mice. Palpable masses were seen in the AKR1B8−/− mice only, not in wild-type. Conclusions: AKR1B8 is a critical protein in the proliferation and injury repair of the colonic epithelium and in the pathogenesis of ulcerative colitis and CAC, being a new etiopathogenic factor of these diseases. Clin Cancer Res; 21(6); 1466–76. ©2014 AACR." @default.
- W2103445961 created "2016-06-24" @default.
- W2103445961 creator A5009966429 @default.
- W2103445961 creator A5023886244 @default.
- W2103445961 creator A5031928873 @default.
- W2103445961 creator A5034347018 @default.
- W2103445961 creator A5045634580 @default.
- W2103445961 creator A5046720476 @default.
- W2103445961 creator A5054603016 @default.
- W2103445961 creator A5057396387 @default.
- W2103445961 creator A5058212805 @default.
- W2103445961 creator A5063441337 @default.
- W2103445961 creator A5063732125 @default.
- W2103445961 creator A5070435488 @default.
- W2103445961 creator A5070584073 @default.
- W2103445961 creator A5071580660 @default.
- W2103445961 creator A5074110801 @default.
- W2103445961 creator A5078243970 @default.
- W2103445961 creator A5081448424 @default.
- W2103445961 creator A5084169173 @default.
- W2103445961 date "2015-03-12" @default.
- W2103445961 modified "2023-09-30" @default.
- W2103445961 title "Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice" @default.
- W2103445961 cites W1855226200 @default.
- W2103445961 cites W1972987064 @default.
- W2103445961 cites W1981327571 @default.
- W2103445961 cites W1984121660 @default.
- W2103445961 cites W1988924112 @default.
- W2103445961 cites W2003920262 @default.
- W2103445961 cites W2006239354 @default.
- W2103445961 cites W2008360112 @default.
- W2103445961 cites W2014218268 @default.
- W2103445961 cites W2015336843 @default.
- W2103445961 cites W2015545224 @default.
- W2103445961 cites W2016301107 @default.
- W2103445961 cites W2018620221 @default.
- W2103445961 cites W2018815492 @default.
- W2103445961 cites W2022245027 @default.
- W2103445961 cites W2024820884 @default.
- W2103445961 cites W2027707599 @default.
- W2103445961 cites W2033633290 @default.
- W2103445961 cites W2037093159 @default.
- W2103445961 cites W2041536661 @default.
- W2103445961 cites W2042664188 @default.
- W2103445961 cites W2058127667 @default.
- W2103445961 cites W2058848674 @default.
- W2103445961 cites W2062661305 @default.
- W2103445961 cites W2063731747 @default.
- W2103445961 cites W2075303826 @default.
- W2103445961 cites W2078621117 @default.
- W2103445961 cites W2082884465 @default.
- W2103445961 cites W2087568865 @default.
- W2103445961 cites W2091973116 @default.
- W2103445961 cites W2095692554 @default.
- W2103445961 cites W2104903275 @default.
- W2103445961 cites W2116761160 @default.
- W2103445961 cites W2121153992 @default.
- W2103445961 cites W2124676948 @default.
- W2103445961 cites W2124806794 @default.
- W2103445961 cites W2125063590 @default.
- W2103445961 cites W2141802511 @default.
- W2103445961 cites W2147923982 @default.
- W2103445961 cites W2148310694 @default.
- W2103445961 cites W2153724086 @default.
- W2103445961 cites W2154544743 @default.
- W2103445961 cites W2159940977 @default.
- W2103445961 cites W2164136578 @default.
- W2103445961 cites W2164531086 @default.
- W2103445961 cites W2166281548 @default.
- W2103445961 cites W2166292243 @default.
- W2103445961 cites W2168982546 @default.
- W2103445961 cites W2606282939 @default.
- W2103445961 cites W4230633180 @default.
- W2103445961 doi "https://doi.org/10.1158/1078-0432.ccr-14-2072" @default.
- W2103445961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4359965" @default.
- W2103445961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25538260" @default.
- W2103445961 hasPublicationYear "2015" @default.
- W2103445961 type Work @default.
- W2103445961 sameAs 2103445961 @default.
- W2103445961 citedByCount "38" @default.
- W2103445961 countsByYear W21034459612015 @default.
- W2103445961 countsByYear W21034459612016 @default.
- W2103445961 countsByYear W21034459612017 @default.
- W2103445961 countsByYear W21034459612018 @default.
- W2103445961 countsByYear W21034459612019 @default.
- W2103445961 countsByYear W21034459612020 @default.
- W2103445961 countsByYear W21034459612021 @default.
- W2103445961 countsByYear W21034459612022 @default.
- W2103445961 countsByYear W21034459612023 @default.
- W2103445961 crossrefType "journal-article" @default.
- W2103445961 hasAuthorship W2103445961A5009966429 @default.
- W2103445961 hasAuthorship W2103445961A5023886244 @default.
- W2103445961 hasAuthorship W2103445961A5031928873 @default.
- W2103445961 hasAuthorship W2103445961A5034347018 @default.
- W2103445961 hasAuthorship W2103445961A5045634580 @default.
- W2103445961 hasAuthorship W2103445961A5046720476 @default.
- W2103445961 hasAuthorship W2103445961A5054603016 @default.
- W2103445961 hasAuthorship W2103445961A5057396387 @default.