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- W2103447802 endingPage "1277" @default.
- W2103447802 startingPage "1265" @default.
- W2103447802 abstract "The eye lens is avascular, deriving nutrients from the aqueous and vitreous humours. It is, however, unclear which mechanisms mediate the transfer of solutes between these humours and the lens' fibre cells (FCs). In this review, we integrate the published data with the previously unpublished ultrastructural, dye loading and magnetic resonance imaging results. The picture emerging is that solute transfer between the humours and the fibre mass is determined by four processes: (i) paracellular transport of ions, water and small molecules along the intercellular spaces between epithelial and FCs, driven by Na + -leak conductance; (ii) membrane transport of such solutes from the intercellular spaces into the fibre cytoplasm by specific carriers and transporters; (iii) gap-junctional coupling mediating solute flux between superficial and deeper fibres, Na + /K + -ATPase-driven efflux of waste products in the equator, and electrical coupling of fibres; and (iv) transcellular transfer via caveoli and coated vesicles for the uptake of macromolecules and cholesterol. There is evidence that the Na + -driven influx of solutes occurs via paracellular and membrane transport and the Na + /K + -ATPase-driven efflux of waste products via gap junctions. This micro-circulation is likely restricted to the superficial cortex and nearly absent beyond the zone of organelle loss, forming a solute exchange barrier in the lens." @default.
- W2103447802 created "2016-06-24" @default.
- W2103447802 creator A5006497097 @default.
- W2103447802 creator A5020023657 @default.
- W2103447802 creator A5027617773 @default.
- W2103447802 creator A5062865460 @default.
- W2103447802 creator A5091048090 @default.
- W2103447802 date "2011-04-27" @default.
- W2103447802 modified "2023-09-28" @default.
- W2103447802 title "Homeostasis in the vertebrate lens: mechanisms of solute exchange" @default.
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