FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103451351> ?p ?o ?g. }

• W2103451351 endingPage "6922" @default.
• W2103451351 startingPage "6913" @default.
• W2103451351 abstract "Delta1, Jagged1, and Jagged2, commonly designated Delta/Serrate/LAG-2 (DSL) proteins, are known to be ligands for Notch1. However, it has been less understood whether they are ligands for Notch receptors other than Notch1. Meanwhile, ligand-induced cleavage and nuclear translocation of the Notch protein are considered to be fundamental for Notch signaling, yet direct observation of the behavior of the Notch molecule after ligand binding, including cleavage and nuclear translocation, has been lacking. In this report, we investigated these issues for Notch2. All of the three DSL proteins bound to endogenous Notch2 on the surface of BaF3 cells, although characteristics of Jagged2 for binding to Notch2 apparently differed from that of Delta1 and Jagged1. After binding, the three DSL proteins induced cleavage of the membrane-spanning subunit of Notch2 (Notch2TM), which occurred within 15 min. In a simultaneous time course, the cleaved fragment of Notch2TMwas translocated into the nucleus. Interestingly, the cleaved Notch2 fragment was hyperphosphorylated also in a time-dependent manner. Finally, binding of DSL proteins to Notch2 also activated the transcription of reporter genes driven by the RBP-Jκ-responsive promoter. Together, these data indicate that all of these DSL proteins function as ligands for Notch2. Moreover, the findings of rapid cleavage, nuclear translocation, and phosphorylation of Notch2 after ligand binding facilitate the understanding of the Notch signaling." @default.
• W2103451351 created "2016-06-24" @default.
• W2103451351 creator A5009975594 @default.
• W2103451351 creator A5011755925 @default.
• W2103451351 creator A5055406060 @default.
• W2103451351 creator A5062792348 @default.
• W2103451351 creator A5067804516 @default.
• W2103451351 creator A5080083757 @default.
• W2103451351 creator A5081126904 @default.
• W2103451351 creator A5085709435 @default.
• W2103451351 creator A5088372604 @default.
• W2103451351 date "2000-09-01" @default.
• W2103451351 modified "2023-10-16" @default.
• W2103451351 title "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2" @default.
• W2103451351 cites W1499659548 @default.
• W2103451351 cites W1660631781 @default.
• W2103451351 cites W1675105744 @default.
• W2103451351 cites W1902852561 @default.
• W2103451351 cites W1905183026 @default.
• W2103451351 cites W1909000005 @default.
• W2103451351 cites W1920902362 @default.
• W2103451351 cites W1968343429 @default.
• W2103451351 cites W1971814935 @default.
• W2103451351 cites W1975730939 @default.
• W2103451351 cites W1980212327 @default.
• W2103451351 cites W1981780292 @default.
• W2103451351 cites W1987801591 @default.
• W2103451351 cites W1994471759 @default.
• W2103451351 cites W1995900441 @default.
• W2103451351 cites W2000550532 @default.
• W2103451351 cites W2018527149 @default.
• W2103451351 cites W2018572618 @default.
• W2103451351 cites W2025748388 @default.
• W2103451351 cites W2027128159 @default.
• W2103451351 cites W2031018864 @default.
• W2103451351 cites W2034535603 @default.
• W2103451351 cites W2039092330 @default.
• W2103451351 cites W2039333302 @default.
• W2103451351 cites W2040362901 @default.
• W2103451351 cites W2044354518 @default.
• W2103451351 cites W2045390772 @default.
• W2103451351 cites W2046928493 @default.
• W2103451351 cites W2047409722 @default.
• W2103451351 cites W2049144240 @default.
• W2103451351 cites W2061738087 @default.
• W2103451351 cites W2064049283 @default.
• W2103451351 cites W2068425472 @default.
• W2103451351 cites W2077309544 @default.
• W2103451351 cites W2083847717 @default.
• W2103451351 cites W2087871321 @default.
• W2103451351 cites W2088969512 @default.
• W2103451351 cites W2094690446 @default.
• W2103451351 cites W2100699398 @default.
• W2103451351 cites W2104629362 @default.
• W2103451351 cites W2114213130 @default.
• W2103451351 cites W2114688668 @default.
• W2103451351 cites W2118623951 @default.
• W2103451351 cites W2118903548 @default.
• W2103451351 cites W2124220437 @default.
• W2103451351 cites W2129092300 @default.
• W2103451351 cites W2129952102 @default.
• W2103451351 cites W2131004933 @default.
• W2103451351 cites W2132884452 @default.
• W2103451351 cites W2140553945 @default.
• W2103451351 cites W2143275370 @default.
• W2103451351 cites W2143760153 @default.
• W2103451351 cites W2146399729 @default.
• W2103451351 cites W2146660065 @default.
• W2103451351 cites W2150792687 @default.
• W2103451351 cites W2153360321 @default.
• W2103451351 cites W2153838631 @default.
• W2103451351 cites W2154079565 @default.
• W2103451351 cites W2154861644 @default.
• W2103451351 cites W2162271468 @default.
• W2103451351 cites W2164772734 @default.
• W2103451351 cites W2171623512 @default.
• W2103451351 cites W2185154911 @default.
• W2103451351 cites W2203884901 @default.
• W2103451351 cites W2301310480 @default.
• W2103451351 doi "https://doi.org/10.1128/mcb.20.18.6913-6922.2000" @default.
• W2103451351 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/88767" @default.
• W2103451351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10958687" @default.
• W2103451351 hasPublicationYear "2000" @default.
• W2103451351 type Work @default.
• W2103451351 sameAs 2103451351 @default.
• W2103451351 citedByCount "155" @default.
• W2103451351 countsByYear W21034513512012 @default.
• W2103451351 countsByYear W21034513512013 @default.
• W2103451351 countsByYear W21034513512014 @default.
• W2103451351 countsByYear W21034513512015 @default.
• W2103451351 countsByYear W21034513512016 @default.
• W2103451351 countsByYear W21034513512017 @default.
• W2103451351 countsByYear W21034513512018 @default.
• W2103451351 countsByYear W21034513512019 @default.
• W2103451351 countsByYear W21034513512020 @default.
• W2103451351 countsByYear W21034513512021 @default.
• W2103451351 countsByYear W21034513512022 @default.
• W2103451351 crossrefType "journal-article" @default.

• next