Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103452500> ?p ?o ?g. }
- W2103452500 endingPage "57" @default.
- W2103452500 startingPage "47" @default.
- W2103452500 abstract "Rat fetal spinal cord (FSC) tissue, naturally enriched with interneuronal progenitors, was introduced into high cervical, hemi-resection (Hx) lesions. Electrophysiological analyses were conducted to determine if such grafts exhibit physiologically-patterned neuronal activity and if stimuli which increase respiratory motor output also alter donor neuron bursting. Three months following transplantation, the bursting activity of FSC neurons and the contralateral phrenic nerve were recorded in anesthetized rats during a normoxic baseline period and brief respiratory challenges. Spontaneous neuronal activity was detected in 80% of the FSC transplants, and autocorrelation of action potential spikes revealed distinct correlogram peaks in 87% of neurons. At baseline, the average discharge frequency of graft neurons was 13.0 ± 1.7 Hz, and discharge frequency increased during a hypoxic respiratory challenge (p < 0.001). Parallel studies in unanesthetized rats showed that FSC tissue recipients had larger inspiratory tidal volumes during brief hypoxic exposures (p < 0.05 vs. C2Hx rats). Anatomical connectivity was explored in additional graft recipients by injecting a transsynaptic retrograde viral tracer (pseudorabies virus, PRV) directly into matured transplants. Neuronal labeling occurred throughout graft tissues and also in the host spinal cord and brainstem nuclei, including those associated with respiratory control. These results underscore the neuroplastic potential of host–graft interactions and training approaches to enhance functional integration within targeted spinal circuitry." @default.
- W2103452500 created "2016-06-24" @default.
- W2103452500 creator A5004750961 @default.
- W2103452500 creator A5005227316 @default.
- W2103452500 creator A5011201539 @default.
- W2103452500 creator A5012981548 @default.
- W2103452500 creator A5026177743 @default.
- W2103452500 creator A5038319158 @default.
- W2103452500 creator A5078454883 @default.
- W2103452500 creator A5090559862 @default.
- W2103452500 date "2014-01-01" @default.
- W2103452500 modified "2023-10-11" @default.
- W2103452500 title "Intraspinal transplantation and modulation of donor neuron electrophysiological activity" @default.
- W2103452500 cites W147668072 @default.
- W2103452500 cites W1492472473 @default.
- W2103452500 cites W1496181771 @default.
- W2103452500 cites W1506138590 @default.
- W2103452500 cites W1681249975 @default.
- W2103452500 cites W1961081041 @default.
- W2103452500 cites W1971852834 @default.
- W2103452500 cites W1972797102 @default.
- W2103452500 cites W1973604867 @default.
- W2103452500 cites W1977982910 @default.
- W2103452500 cites W1978509584 @default.
- W2103452500 cites W1979922994 @default.
- W2103452500 cites W1982480010 @default.
- W2103452500 cites W1983970487 @default.
- W2103452500 cites W1989560803 @default.
- W2103452500 cites W1989586615 @default.
- W2103452500 cites W1995374378 @default.
- W2103452500 cites W1998633995 @default.
- W2103452500 cites W1998753032 @default.
- W2103452500 cites W1999574759 @default.
- W2103452500 cites W2000056002 @default.
- W2103452500 cites W2009859845 @default.
- W2103452500 cites W2013194351 @default.
- W2103452500 cites W2019432277 @default.
- W2103452500 cites W2022396588 @default.
- W2103452500 cites W2026447636 @default.
- W2103452500 cites W2027982922 @default.
- W2103452500 cites W2028703178 @default.
- W2103452500 cites W2032438445 @default.
- W2103452500 cites W2034226385 @default.
- W2103452500 cites W2041986134 @default.
- W2103452500 cites W2044913429 @default.
- W2103452500 cites W2047423696 @default.
- W2103452500 cites W2051742717 @default.
- W2103452500 cites W2054355149 @default.
- W2103452500 cites W2056745812 @default.
- W2103452500 cites W2059372622 @default.
- W2103452500 cites W2066223046 @default.
- W2103452500 cites W2067019666 @default.
- W2103452500 cites W2069869045 @default.
- W2103452500 cites W2071565576 @default.
- W2103452500 cites W2076422538 @default.
- W2103452500 cites W2076687893 @default.
- W2103452500 cites W2076828182 @default.
- W2103452500 cites W2091298636 @default.
- W2103452500 cites W2094145315 @default.
- W2103452500 cites W2097509747 @default.
- W2103452500 cites W2100615567 @default.
- W2103452500 cites W2102010332 @default.
- W2103452500 cites W2117712478 @default.
- W2103452500 cites W2119347467 @default.
- W2103452500 cites W2123048941 @default.
- W2103452500 cites W2130614082 @default.
- W2103452500 cites W2135315011 @default.
- W2103452500 cites W2135395238 @default.
- W2103452500 cites W2135557712 @default.
- W2103452500 cites W2144373409 @default.
- W2103452500 cites W2145928890 @default.
- W2103452500 cites W2151241124 @default.
- W2103452500 cites W2157851792 @default.
- W2103452500 cites W2164466707 @default.
- W2103452500 cites W2260815013 @default.
- W2103452500 cites W2272744191 @default.
- W2103452500 cites W2335909090 @default.
- W2103452500 cites W2413461190 @default.
- W2103452500 doi "https://doi.org/10.1016/j.expneurol.2013.10.016" @default.
- W2103452500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893055" @default.
- W2103452500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24192152" @default.
- W2103452500 hasPublicationYear "2014" @default.
- W2103452500 type Work @default.
- W2103452500 sameAs 2103452500 @default.
- W2103452500 citedByCount "40" @default.
- W2103452500 countsByYear W21034525002014 @default.
- W2103452500 countsByYear W21034525002015 @default.
- W2103452500 countsByYear W21034525002016 @default.
- W2103452500 countsByYear W21034525002017 @default.
- W2103452500 countsByYear W21034525002018 @default.
- W2103452500 countsByYear W21034525002019 @default.
- W2103452500 countsByYear W21034525002020 @default.
- W2103452500 countsByYear W21034525002021 @default.
- W2103452500 countsByYear W21034525002022 @default.
- W2103452500 countsByYear W21034525002023 @default.
- W2103452500 crossrefType "journal-article" @default.
- W2103452500 hasAuthorship W2103452500A5004750961 @default.
- W2103452500 hasAuthorship W2103452500A5005227316 @default.