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• W2103452894 abstract "BackgroundThere is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans.ObjectivesThis study was designed to assess the effect of short-and long-term O3 exposures on biomarkers of oxidative stress in healthy individuals.MethodsBiomarkers of lipid peroxidation, 8-isoprostane (8-iso-PGF), and antioxidant capacity ferric reducing ability of plasma (FRAP) were analyzed in two groups of healthy college students with broad ranges of ambient O3 exposure during their lifetimes and previous summer recess either in Los Angeles (LA, n = 59) or the San Francisco Bay Area (SF, n = 61).ResultsEstimated 2-week, 1-month, and lifetime O3 exposures were significantly correlated with elevated 8-iso-PGF. Elevated summertime exposures resulted in the LA group having higher levels of 8-iso-PGF than the SF group (p = 0.02). Within each location, males and females had similar 8-iso-PGF. No regional difference in FRAP was observed, with significantly higher FRAP in males in both groups (SF: p = 0.002; LA: p = 0.004). An exposure chamber substudy (n = 15) also showed a significant increase in 8-iso-PGF as well as an inhibition of FRAP immediately after a 4-hr exposure to 200 ppb O3, with near normalization by 18 hr in both biomarkers.ConclusionsLong-term exposure to O3 is associated with elevated 8-iso-PGF, which suggests that 8-iso-PGF is a good biomarker of oxidative damage related to air pollution." @default.
• W2103452894 created "2016-06-24" @default.
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• W2103452894 date "2007-12-01" @default.
• W2103452894 modified "2023-09-29" @default.
• W2103452894 title "Effects of Chronic and Acute Ozone Exposure on Lipid Peroxidation and Antioxidant Capacity in Healthy Young Adults" @default.
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• W2103452894 doi "https://doi.org/10.1289/ehp.10294" @default.
• W2103452894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2137098" @default.
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• W2103452894 hasPublicationYear "2007" @default.
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