Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103453110> ?p ?o ?g. }
- W2103453110 endingPage "53" @default.
- W2103453110 startingPage "40" @default.
- W2103453110 abstract "The involvement of Rho GTPases in signal transduction pathways leading to transcription activation is one of the major roles of this family of GTPases. Thus, the identification of transcription factors regulated by Rho GTPases and the understanding of the mechanisms of their activation and its biological outcome are of great interest. Here, we provide evidence that Rho GTPases modulate Stat5a, a transcription factor of the family of signal transducers and activators of transcription. RhoA triggers tyrosine phosphorylation (Y696) of Stat5a via a JAK2-dependent mechanism and promotes DNA-binding activity of Stat5a. Tyrosine phosphorylation of Stat5a is also stimulated physiologically by lysophosphatidic acid (LPA) in a Rho-dependent manner. Simultaneously, RhoA reduces serine phosphorylation of Stat5a at both serine residues S726 and S780, resulting in a further increase of activity as defined by mutagenesis experiments. Furthermore, serine dephosphorylation of Stat5a by RhoA does not take place by down-modulation of either JNK1, MEK1, or p38 MAP kinases, as determined by transfection experiments or chemical inhibition of both MEK1, p38, and JNK serine kinases. Thus, RhoA regulates Stat5a via tyrosine phosphorylation and via a yet to be determined novel down-modulating pathway that involves serine dephosphorylation. Finally, we provide evidence for a role of Stat5a in RhoA-induced epithelial-to-mesenchymal transition with concomitant increase in vimentin expression, E-cadherin down-regulation, and cell motility." @default.
- W2103453110 created "2016-06-24" @default.
- W2103453110 creator A5011961061 @default.
- W2103453110 creator A5044766458 @default.
- W2103453110 creator A5054941477 @default.
- W2103453110 creator A5065798455 @default.
- W2103453110 date "2003-01-01" @default.
- W2103453110 modified "2023-09-24" @default.
- W2103453110 title "STAT5a Activation Mediates the Epithelial to Mesenchymal Transition Induced by Oncogenic RhoA." @default.
- W2103453110 cites W1486018587 @default.
- W2103453110 cites W1496263460 @default.
- W2103453110 cites W1553277501 @default.
- W2103453110 cites W1598659248 @default.
- W2103453110 cites W1649526546 @default.
- W2103453110 cites W1687855674 @default.
- W2103453110 cites W1803183847 @default.
- W2103453110 cites W1905957625 @default.
- W2103453110 cites W1949238489 @default.
- W2103453110 cites W1963780296 @default.
- W2103453110 cites W1969814333 @default.
- W2103453110 cites W1970523400 @default.
- W2103453110 cites W1971018030 @default.
- W2103453110 cites W1973658424 @default.
- W2103453110 cites W1974392769 @default.
- W2103453110 cites W1976568695 @default.
- W2103453110 cites W1978162225 @default.
- W2103453110 cites W1983628734 @default.
- W2103453110 cites W1986178012 @default.
- W2103453110 cites W1991987237 @default.
- W2103453110 cites W1993034428 @default.
- W2103453110 cites W1993641273 @default.
- W2103453110 cites W1994479081 @default.
- W2103453110 cites W2010776189 @default.
- W2103453110 cites W2016826417 @default.
- W2103453110 cites W2023687572 @default.
- W2103453110 cites W2025637687 @default.
- W2103453110 cites W2030624761 @default.
- W2103453110 cites W2030762806 @default.
- W2103453110 cites W2030865745 @default.
- W2103453110 cites W2037921638 @default.
- W2103453110 cites W2040495689 @default.
- W2103453110 cites W2041069947 @default.
- W2103453110 cites W2042951392 @default.
- W2103453110 cites W2044219252 @default.
- W2103453110 cites W2053257956 @default.
- W2103453110 cites W2054195011 @default.
- W2103453110 cites W2056078744 @default.
- W2103453110 cites W2063623240 @default.
- W2103453110 cites W2066629426 @default.
- W2103453110 cites W2067626539 @default.
- W2103453110 cites W2070512478 @default.
- W2103453110 cites W2072400772 @default.
- W2103453110 cites W2074133165 @default.
- W2103453110 cites W2077193261 @default.
- W2103453110 cites W2077349366 @default.
- W2103453110 cites W2077792958 @default.
- W2103453110 cites W2078475797 @default.
- W2103453110 cites W2079607432 @default.
- W2103453110 cites W2080590768 @default.
- W2103453110 cites W2080778311 @default.
- W2103453110 cites W2083802827 @default.
- W2103453110 cites W2085129546 @default.
- W2103453110 cites W2087251749 @default.
- W2103453110 cites W2098279326 @default.
- W2103453110 cites W2103933335 @default.
- W2103453110 cites W2105550924 @default.
- W2103453110 cites W2118650242 @default.
- W2103453110 cites W2118833233 @default.
- W2103453110 cites W2133415297 @default.
- W2103453110 cites W2133424481 @default.
- W2103453110 cites W2141353482 @default.
- W2103453110 cites W2145416278 @default.
- W2103453110 cites W2164465986 @default.
- W2103453110 cites W2164894218 @default.
- W2103453110 cites W2168091755 @default.
- W2103453110 cites W2170906235 @default.
- W2103453110 cites W2226281711 @default.
- W2103453110 cites W2312394405 @default.
- W2103453110 cites W2312919696 @default.
- W2103453110 cites W2320359800 @default.
- W2103453110 cites W326967406 @default.
- W2103453110 cites W92308392 @default.
- W2103453110 doi "https://doi.org/10.1091/mbc.e02-08-0454" @default.
- W2103453110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140226" @default.
- W2103453110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12529425" @default.
- W2103453110 hasPublicationYear "2003" @default.
- W2103453110 type Work @default.
- W2103453110 sameAs 2103453110 @default.
- W2103453110 citedByCount "35" @default.
- W2103453110 countsByYear W21034531102012 @default.
- W2103453110 countsByYear W21034531102013 @default.
- W2103453110 countsByYear W21034531102014 @default.
- W2103453110 countsByYear W21034531102017 @default.
- W2103453110 countsByYear W21034531102018 @default.
- W2103453110 countsByYear W21034531102019 @default.
- W2103453110 countsByYear W21034531102020 @default.
- W2103453110 countsByYear W21034531102021 @default.
- W2103453110 countsByYear W21034531102022 @default.