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• W2103455940 abstract "Abstract Homologous recombination and nonhomologous end joining (NHEJ) are important DNA double-strand break repair pathways in many organisms. C. elegans strains harboring mutations in the cku-70, cku-80, or lig-4 NHEJ genes displayed multiple developmental abnormalities in response to radiation-induced DNA damage in noncycling somatic cells. These phenotypes did not result from S-phase, DNA damage, or mitotic checkpoints, apoptosis, or stress response pathways that regulate dauer formation. However, an additional defect in him-10, a kinetochore component, synergized with NHEJ mutations for the radiation-induced developmental phenotypes, suggesting that they may be triggered by mis-segregation of chromosome fragments. Although NHEJ was an important DNA repair pathway for noncycling somatic cells in C. elegans, homologous recombination was used to repair radiation-induced DNA damage in cycling somatic cells and in germ cells at all times. Noncycling germ cells that depended on homologous recombination underwent cell cycle arrest in G2, whereas noncycling somatic cells that depended on NHEJ arrested in G1, suggesting that cell cycle phase may modulate DNA repair during development. We conclude that error-prone NHEJ plays little or no role in DNA repair in C. elegans germ cells, possibly ensuring homology-based double-strand break repair and transmission of a stable genome from one generation to the next." @default.
• W2103455940 created "2016-06-24" @default.
• W2103455940 creator A5004603287 @default.
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• W2103455940 date "2006-07-01" @default.
• W2103455940 modified "2023-09-30" @default.
• W2103455940 title "Developmental Modulation of Nonhomologous End Joining in <i>Caenorhabditis elegans</i>" @default.
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• W2103455940 doi "https://doi.org/10.1534/genetics.106.058628" @default.
• W2103455940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1526663" @default.
• W2103455940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16702421" @default.
• W2103455940 hasPublicationYear "2006" @default.
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