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• W2103456058 abstract "The aim of the present study was to investigate the effect of γ-aminobutyric acid transporter-1 (GAT-1) on the anxiety-like behaviors and cognitive function in knockout mice. In total, 20 adult male mice were divided into two groups, namely the GAT-1 knockout (GAT-1-/-) and wild-type (WT) groups. The open field test, elevated 0-maze (EZM) and Morris water maze were used to evaluate changes in anxiety-like behaviors and cognitive function. Compared with the WT mice, GAT-1-/- mice made more entries and spent a longer time within the central area, traveling a greater distance, during the open field test (P<0.05). The EZM revealed that GAT-1-/- mice spent more time in the open sectors and made more total entries when compared with the WT mice (P<0.01). Observations from the two tests indicated reduced anxiety-like behaviors in the GAT-1-/- mice. During the learning session using a Morris water maze, the latency to find the platform was significantly longer in the GAT-1-/- mice when compared with the WT mice (P<0.01). In addition, during the probe test, the GAT-1-/- mice spent less time in the target quadrant and more time in the opposite quadrant when compared with the WT mice (P<0.01); thus, the cognitive function in the GAT-1-/- mice was impaired. Therefore, the results demonstrated that the anxiety-like behaviors were reduced and cognitive function was impaired in GAT-1 knockout mice, indicating that GAT-1 is involved in anxiety and cognitive functions." @default.
• W2103456058 created "2016-06-24" @default.
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• W2103456058 date "2015-06-15" @default.
• W2103456058 modified "2023-10-09" @default.
• W2103456058 title "γ-aminobutyric acid transporter-1 is involved in anxiety-like behaviors and cognitive function in knockout mice" @default.
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• W2103456058 doi "https://doi.org/10.3892/etm.2015.2577" @default.
• W2103456058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4509144" @default.
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