Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103457817> ?p ?o ?g. }
- W2103457817 endingPage "340" @default.
- W2103457817 startingPage "332" @default.
- W2103457817 abstract "Craniosynostosis occurs in one of 2500 live human births and may manifest as craniofacial disfiguration, seizure, and blindness. Craniotomy is performed to reshape skull bones and resect synostosed cranial sutures. We demonstrate for the first time that autologous mesenchymal stem cells (MSCs) and controlled-released TGFbeta3 reduced surgical trauma to localized osteotomy and minimized osteogenesis in a rat craniosynostosis model. Approximately 0.5 mL tibial marrow content was aspirated to isolate mononucleated and adherent cells that were characterized as MSCs. Upon resecting the synostosed suture, autologous MSCs in collagen carriers with microencapsulated TGFbeta3 (1 ng/mL) generated cranial suture analogs characterized as bone-soft tissue-bone interface by quantitative histomorphometric and microCT analyses. Thus, surgical trauma in craniosynostosis can be minimized by a biologically viable implant. We speculate that proportionally larger amounts of human marrow aspirates participate in the healing of craniosynostosis defects in patients. The engineered soft tissue-bone interface may have implications in the repair of tendons, ligaments, periosteum and periodontal ligament." @default.
- W2103457817 created "2016-06-24" @default.
- W2103457817 creator A5017967519 @default.
- W2103457817 creator A5020929474 @default.
- W2103457817 creator A5033410736 @default.
- W2103457817 creator A5035311437 @default.
- W2103457817 date "2008-02-01" @default.
- W2103457817 modified "2023-09-25" @default.
- W2103457817 title "Autologous stem cell regeneration in craniosynostosis" @default.
- W2103457817 cites W1575237019 @default.
- W2103457817 cites W1600003673 @default.
- W2103457817 cites W168458466 @default.
- W2103457817 cites W1965661225 @default.
- W2103457817 cites W1974207011 @default.
- W2103457817 cites W1975983201 @default.
- W2103457817 cites W1985942181 @default.
- W2103457817 cites W1987417700 @default.
- W2103457817 cites W1990214734 @default.
- W2103457817 cites W1991508035 @default.
- W2103457817 cites W1996803044 @default.
- W2103457817 cites W2001561232 @default.
- W2103457817 cites W2002956851 @default.
- W2103457817 cites W2009773280 @default.
- W2103457817 cites W2011155633 @default.
- W2103457817 cites W2013083466 @default.
- W2103457817 cites W2023894506 @default.
- W2103457817 cites W2025682321 @default.
- W2103457817 cites W2028798894 @default.
- W2103457817 cites W2032021593 @default.
- W2103457817 cites W2032820579 @default.
- W2103457817 cites W2034822820 @default.
- W2103457817 cites W2042835261 @default.
- W2103457817 cites W2059289539 @default.
- W2103457817 cites W2061271035 @default.
- W2103457817 cites W2067957303 @default.
- W2103457817 cites W2079416369 @default.
- W2103457817 cites W2080955594 @default.
- W2103457817 cites W2085001489 @default.
- W2103457817 cites W2085029389 @default.
- W2103457817 cites W2085352933 @default.
- W2103457817 cites W2090947054 @default.
- W2103457817 cites W2095115114 @default.
- W2103457817 cites W2102169821 @default.
- W2103457817 cites W2102894828 @default.
- W2103457817 cites W2114706538 @default.
- W2103457817 cites W2117836192 @default.
- W2103457817 cites W2119610794 @default.
- W2103457817 cites W2122375787 @default.
- W2103457817 cites W2124622147 @default.
- W2103457817 cites W2128550660 @default.
- W2103457817 cites W2132620372 @default.
- W2103457817 cites W2133557011 @default.
- W2103457817 cites W2140370234 @default.
- W2103457817 cites W2153156179 @default.
- W2103457817 cites W2154897463 @default.
- W2103457817 cites W2161469883 @default.
- W2103457817 cites W2172171123 @default.
- W2103457817 cites W4293542337 @default.
- W2103457817 doi "https://doi.org/10.1016/j.bone.2007.10.004" @default.
- W2103457817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4035041" @default.
- W2103457817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18023269" @default.
- W2103457817 hasPublicationYear "2008" @default.
- W2103457817 type Work @default.
- W2103457817 sameAs 2103457817 @default.
- W2103457817 citedByCount "26" @default.
- W2103457817 countsByYear W21034578172012 @default.
- W2103457817 countsByYear W21034578172014 @default.
- W2103457817 countsByYear W21034578172015 @default.
- W2103457817 countsByYear W21034578172017 @default.
- W2103457817 countsByYear W21034578172018 @default.
- W2103457817 countsByYear W21034578172019 @default.
- W2103457817 countsByYear W21034578172021 @default.
- W2103457817 countsByYear W21034578172022 @default.
- W2103457817 crossrefType "journal-article" @default.
- W2103457817 hasAuthorship W2103457817A5017967519 @default.
- W2103457817 hasAuthorship W2103457817A5020929474 @default.
- W2103457817 hasAuthorship W2103457817A5033410736 @default.
- W2103457817 hasAuthorship W2103457817A5035311437 @default.
- W2103457817 hasBestOaLocation W21034578172 @default.
- W2103457817 hasConcept C105702510 @default.
- W2103457817 hasConcept C118552586 @default.
- W2103457817 hasConcept C136948725 @default.
- W2103457817 hasConcept C141071460 @default.
- W2103457817 hasConcept C142724271 @default.
- W2103457817 hasConcept C171056886 @default.
- W2103457817 hasConcept C198826908 @default.
- W2103457817 hasConcept C2777327002 @default.
- W2103457817 hasConcept C2777674748 @default.
- W2103457817 hasConcept C2778871575 @default.
- W2103457817 hasConcept C2779300802 @default.
- W2103457817 hasConcept C2779302956 @default.
- W2103457817 hasConcept C2781245598 @default.
- W2103457817 hasConcept C71924100 @default.
- W2103457817 hasConcept C8337478 @default.
- W2103457817 hasConcept C86803240 @default.
- W2103457817 hasConcept C95444343 @default.
- W2103457817 hasConceptScore W2103457817C105702510 @default.
- W2103457817 hasConceptScore W2103457817C118552586 @default.