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• W2103458975 abstract "Tissue factor (TF), the main trigger of coagulation is important in the propagation of cardiovascular diseases. Based on an in vitro study, we hypothesised that enalapril may blunt the endotoxin-induced, TF-triggered coagulation in humans.In a randomised, controlled trial, 30 healthy male volunteers received 2 ng/kg of lipopolysaccharide (LPS) after pre-treatment with placebo or enalapril for 5 days or with enalapril 2 h before LPS infusion.Infusion of LPS increased interleukin-6 levels 400 fold, and induced a 10-fold increase in prothrombin fragment, a fourfold increase in D-dimer, and a fivefold increase in plasmin-antiplasmin complexes. However, pre-treatment with enalapril did not blunt LPS-induced coagulation.Our trial provides evidence against a modulatory role of angiotensin converting enzyme in LPS-induced, TF-triggered coagulation." @default.
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• W2103458975 date "2003-10-15" @default.
• W2103458975 modified "2023-10-04" @default.
• W2103458975 title "Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation" @default.
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• W2103458975 doi "https://doi.org/10.1016/s0008-6363(03)00363-8" @default.
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