FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103459268> ?p ?o ?g. }

• W2103459268 endingPage "375" @default.
• W2103459268 startingPage "365" @default.
• W2103459268 abstract "In contrast with normal subjects where IgA is the main immunoglobulin in the intestine, patients with active inflammatory bowel disease (IBD) produce high concentrations of IgG from intestinal lymphocytes, but the antigens at which these antibodies are directed are unknown. To investigate the specificities of these antibodies mucosal immunoglobulins were isolated from washings taken at endoscopy from 21 control patients with irritable bowel syndrome, 10 control patients with intestinal inflammation due to infection or ischaemia, and 51 patients with IBD: 24 Crohn9s disease (CD, 15 active, nine quiescent), 27 ulcerative colitis (UC, 20 active, seven inactive). Total mucosal IgG was much higher (p < 0.001) in active UC (median 512 micrograms/ml) and active CD (256 micrograms/ml) than in irritable bowel syndrome controls (1.43 micrograms/ml), but not significantly different from controls with non-IBD intestinal inflammation (224 micrograms/ml). Mucosal IgG bound to proteins of a range of non-pathogenic commensal faecal bacteria in active CD; this was higher than in UC (p < 0.01); and both were significantly greater than controls with non-IBD intestinal inflammation (CD p < 0.001, UC p < 0.01) or IBS (p < 0.001 CD and UC). This mucosal IgG binding was shown on western blots and by enzyme linked immunosorbent assay (ELISA) to be principally directed against the bacterial cytoplasmic rather than the membrane proteins. Total mucosal IgA concentrations did not differ between IBD and controls, but the IgA titres against faecal bacteria were lower in UC than controls (p < 0.01). These experiments show that there is an exaggerated mucosal immune response particularly in active CD but also in UC directed against cytoplasmic proteins of bacteria within the intestinal lumen; this implies that in relapse of IBD there is a breakdown of tolerance to the normal commensal flora of the gut." @default.
• W2103459268 created "2016-06-24" @default.
• W2103459268 creator A5011134410 @default.
• W2103459268 creator A5018399191 @default.
• W2103459268 creator A5056626995 @default.
• W2103459268 creator A5061016435 @default.
• W2103459268 creator A5074866560 @default.
• W2103459268 date "1996-03-01" @default.
• W2103459268 modified "2023-10-11" @default.
• W2103459268 title "Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria." @default.
• W2103459268 cites W1603555904 @default.
• W2103459268 cites W166805679 @default.
• W2103459268 cites W1783939890 @default.
• W2103459268 cites W1789416382 @default.
• W2103459268 cites W1870183291 @default.
• W2103459268 cites W1953484494 @default.
• W2103459268 cites W1966495421 @default.
• W2103459268 cites W1985739635 @default.
• W2103459268 cites W1989090634 @default.
• W2103459268 cites W1996649901 @default.
• W2103459268 cites W1997398245 @default.
• W2103459268 cites W2000208875 @default.
• W2103459268 cites W2003456719 @default.
• W2103459268 cites W2004718563 @default.
• W2103459268 cites W2008014387 @default.
• W2103459268 cites W2022661087 @default.
• W2103459268 cites W2022975557 @default.
• W2103459268 cites W2036500213 @default.
• W2103459268 cites W2038627922 @default.
• W2103459268 cites W2040512118 @default.
• W2103459268 cites W2053403899 @default.
• W2103459268 cites W2055861239 @default.
• W2103459268 cites W2073565533 @default.
• W2103459268 cites W2075835026 @default.
• W2103459268 cites W2080195364 @default.
• W2103459268 cites W2087982857 @default.
• W2103459268 cites W2089204801 @default.
• W2103459268 cites W2098638622 @default.
• W2103459268 cites W2114344731 @default.
• W2103459268 cites W2119718862 @default.
• W2103459268 cites W2153950638 @default.
• W2103459268 cites W2157787228 @default.
• W2103459268 cites W2174214567 @default.
• W2103459268 cites W2321679666 @default.
• W2103459268 cites W2328023807 @default.
• W2103459268 cites W2400872289 @default.
• W2103459268 cites W2402628576 @default.
• W2103459268 cites W2402829494 @default.
• W2103459268 cites W2404854108 @default.
• W2103459268 cites W2412687432 @default.
• W2103459268 cites W2413175638 @default.
• W2103459268 cites W2419024389 @default.
• W2103459268 cites W246570585 @default.
• W2103459268 cites W323360299 @default.
• W2103459268 cites W71375807 @default.
• W2103459268 doi "https://doi.org/10.1136/gut.38.3.365" @default.
• W2103459268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1383064" @default.
• W2103459268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8675088" @default.
• W2103459268 hasPublicationYear "1996" @default.
• W2103459268 type Work @default.
• W2103459268 sameAs 2103459268 @default.
• W2103459268 citedByCount "409" @default.
• W2103459268 countsByYear W21034592682012 @default.
• W2103459268 countsByYear W21034592682013 @default.
• W2103459268 countsByYear W21034592682014 @default.
• W2103459268 countsByYear W21034592682015 @default.
• W2103459268 countsByYear W21034592682016 @default.
• W2103459268 countsByYear W21034592682017 @default.
• W2103459268 countsByYear W21034592682018 @default.
• W2103459268 countsByYear W21034592682019 @default.
• W2103459268 countsByYear W21034592682020 @default.
• W2103459268 countsByYear W21034592682021 @default.
• W2103459268 countsByYear W21034592682022 @default.
• W2103459268 countsByYear W21034592682023 @default.
• W2103459268 crossrefType "journal-article" @default.
• W2103459268 hasAuthorship W2103459268A5011134410 @default.
• W2103459268 hasAuthorship W2103459268A5018399191 @default.
• W2103459268 hasAuthorship W2103459268A5056626995 @default.
• W2103459268 hasAuthorship W2103459268A5061016435 @default.
• W2103459268 hasAuthorship W2103459268A5074866560 @default.
• W2103459268 hasBestOaLocation W21034592681 @default.
• W2103459268 hasConcept C126322002 @default.
• W2103459268 hasConcept C159654299 @default.
• W2103459268 hasConcept C203014093 @default.
• W2103459268 hasConcept C2775862500 @default.
• W2103459268 hasConcept C2776914184 @default.
• W2103459268 hasConcept C2778260677 @default.
• W2103459268 hasConcept C2778271842 @default.
• W2103459268 hasConcept C2779102806 @default.
• W2103459268 hasConcept C2779134260 @default.
• W2103459268 hasConcept C2779280984 @default.
• W2103459268 hasConcept C2780479503 @default.
• W2103459268 hasConcept C2780898057 @default.
• W2103459268 hasConcept C2910850605 @default.
• W2103459268 hasConcept C71924100 @default.
• W2103459268 hasConcept C90924648 @default.
• W2103459268 hasConceptScore W2103459268C126322002 @default.
• W2103459268 hasConceptScore W2103459268C159654299 @default.

• next