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- W2103462952 abstract "Purpose: To determine whether rhythm control confers clinical benefits over rate control in patients with newly diagnosed atrial fibrillation (AF).Methods: Adults (≥18 y) with newly diagnosed non-valvular AF and ≥1 stroke risk factor were enrolled (540 sites, 19 countries). Cox proportional hazards model was used to determine the effects of rhythm vs rate control at 1 year, adjusted for antithrombotic treatments and components of CHA2DS2-VASc score.Results: Of the 10,614 adults enrolled, baseline and follow-up data were available in 9258 and 8839 patients, respectively. Patients in the rate control group were older, had higher risk scores and were more likely to have antithrombotic treatments initiated at AF diagnosis (Table 1). Rhythm control was associated with a significantly lower risk of death (absolute rates 1.6% vs 2.7%; adjusted HR 0.73, 95% CI 0.53–0.98; p=0.039) and a numerically lower risk of stroke/systemic embolism (0.9% vs 1.3%; HR 0.68, 95% CI 0.45–1.04; p=0.075). There were no differences in acute coronary syndrome, major bleeding or intracranial haemorrhage.View this table:Baseline characteristicsConclusions: Among patients with newly diagnosed non-valvular AF and ≥1 stroke risk factor, rhythm control seems to be associated with clinical benefits over rate control. However, the two groups differed in many respects, and we may not have been able to adjust for residual confounding. The results must therefore be interpreted with caution." @default.
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- W2103462952 date "2013-08-02" @default.
- W2103462952 modified "2023-09-25" @default.
- W2103462952 title "Outcomes after rhythm versus rate control in patients with atrial fibrillation: the international prospective GARFIELD registry" @default.
- W2103462952 doi "https://doi.org/10.1093/eurheartj/eht307.p551" @default.
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