FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103463753> ?p ?o ?g. }

• W2103463753 endingPage "280" @default.
• W2103463753 startingPage "270" @default.
• W2103463753 abstract "This study was designed to evaluate the protective effect of silymarin (SMN) on varicocele-induced damage in testis and its effects on sperm parameters and on antioxidant status. Wistar rats were divided into three groups: control-sham, varicocele-induced, and SMN-treated varicocelized (50mg/kg, orally) rats. The sperm count, DNA integrity, and histone-protamine transition was evaluated after 42 days. The antioxidant status was analyzed by determining testicular malondialdehyde (MDA) and total thiol molecules (TTM). The endocrine status of the testicular tissue was estimated by counting the normal Leydig cell distribution/mm(2) and by determination of serum testosterone. The expression of E2f1 mRNA was analyzed using RT-PCR. Carbohydrate depletion and lipid foci replacement in germinal cells were examined by histochemical analyses. Silymarin rehabilitated the varicocele-induced Leydig cell degeneration and testosterone reduction. In addition, SMN recovered the varicocele-induced reduction of TTM and lowered significantly (P < 0.05) the varicocele-elevated content of MDA. The SMN treatment resulted in a significant (P < 0.05) down-regulation of the VCL-up-regulated E2f1 mRNA. Silymarin-treated animals were protected from varicocele-induced testicular atrophy and these animals showed a significant (P < 0.05) increase in the percentage of seminiferous tubules with positive tubular differentiation, repopulation, and spermiogenesis indices. Furthermore, SMN improved the varicocele-induced carbohydrate reduction in germinal cells. Our data suggest that in addition to oxidative stress, alteration in the testicular endocrine function plays a crucial role in the pathogenesis of varicocele. Moreover, the protective effects of SMN on varicocele-induced damage may reflect its antioxidant property, which may be mediated via the E2f1 transcription factor." @default.
• W2103463753 created "2016-06-24" @default.
• W2103463753 creator A5037974804 @default.
• W2103463753 creator A5046813391 @default.
• W2103463753 creator A5062142208 @default.
• W2103463753 creator A5074574989 @default.
• W2103463753 date "2013-05-10" @default.
• W2103463753 modified "2023-10-16" @default.
• W2103463753 title "Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement" @default.
• W2103463753 cites W1504555765 @default.
• W2103463753 cites W1775749144 @default.
• W2103463753 cites W1968643339 @default.
• W2103463753 cites W1975349286 @default.
• W2103463753 cites W1980425963 @default.
• W2103463753 cites W1985178609 @default.
• W2103463753 cites W1987200813 @default.
• W2103463753 cites W1987286863 @default.
• W2103463753 cites W1995382021 @default.
• W2103463753 cites W2003239757 @default.
• W2103463753 cites W2012972697 @default.
• W2103463753 cites W2021964661 @default.
• W2103463753 cites W202238227 @default.
• W2103463753 cites W2023590177 @default.
• W2103463753 cites W2024821032 @default.
• W2103463753 cites W2030035824 @default.
• W2103463753 cites W2034876552 @default.
• W2103463753 cites W2047428378 @default.
• W2103463753 cites W2047979773 @default.
• W2103463753 cites W2054684794 @default.
• W2103463753 cites W2067193448 @default.
• W2103463753 cites W2067902786 @default.
• W2103463753 cites W2083747309 @default.
• W2103463753 cites W2092204341 @default.
• W2103463753 cites W2098335475 @default.
• W2103463753 cites W2099980511 @default.
• W2103463753 cites W2114477976 @default.
• W2103463753 cites W2117323496 @default.
• W2103463753 cites W2132323127 @default.
• W2103463753 cites W2133638028 @default.
• W2103463753 cites W2157267009 @default.
• W2103463753 cites W2158292312 @default.
• W2103463753 cites W2167713256 @default.
• W2103463753 cites W2275274443 @default.
• W2103463753 doi "https://doi.org/10.3109/19396368.2013.794253" @default.
• W2103463753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23659554" @default.
• W2103463753 hasPublicationYear "2013" @default.
• W2103463753 type Work @default.
• W2103463753 sameAs 2103463753 @default.
• W2103463753 citedByCount "32" @default.
• W2103463753 countsByYear W21034637532014 @default.
• W2103463753 countsByYear W21034637532015 @default.
• W2103463753 countsByYear W21034637532016 @default.
• W2103463753 countsByYear W21034637532017 @default.
• W2103463753 countsByYear W21034637532018 @default.
• W2103463753 countsByYear W21034637532019 @default.
• W2103463753 countsByYear W21034637532020 @default.
• W2103463753 countsByYear W21034637532021 @default.
• W2103463753 countsByYear W21034637532022 @default.
• W2103463753 countsByYear W21034637532023 @default.
• W2103463753 crossrefType "journal-article" @default.
• W2103463753 hasAuthorship W2103463753A5037974804 @default.
• W2103463753 hasAuthorship W2103463753A5046813391 @default.
• W2103463753 hasAuthorship W2103463753A5062142208 @default.
• W2103463753 hasAuthorship W2103463753A5074574989 @default.
• W2103463753 hasConcept C123765429 @default.
• W2103463753 hasConcept C126322002 @default.
• W2103463753 hasConcept C134018914 @default.
• W2103463753 hasConcept C16685009 @default.
• W2103463753 hasConcept C2776151105 @default.
• W2103463753 hasConcept C2777688143 @default.
• W2103463753 hasConcept C2777736315 @default.
• W2103463753 hasConcept C2778054964 @default.
• W2103463753 hasConcept C2778466210 @default.
• W2103463753 hasConcept C2778575703 @default.
• W2103463753 hasConcept C2779234561 @default.
• W2103463753 hasConcept C2779279991 @default.
• W2103463753 hasConcept C2781087480 @default.
• W2103463753 hasConcept C54355233 @default.
• W2103463753 hasConcept C71315377 @default.
• W2103463753 hasConcept C71924100 @default.
• W2103463753 hasConcept C86803240 @default.
• W2103463753 hasConceptScore W2103463753C123765429 @default.
• W2103463753 hasConceptScore W2103463753C126322002 @default.
• W2103463753 hasConceptScore W2103463753C134018914 @default.
• W2103463753 hasConceptScore W2103463753C16685009 @default.
• W2103463753 hasConceptScore W2103463753C2776151105 @default.
• W2103463753 hasConceptScore W2103463753C2777688143 @default.
• W2103463753 hasConceptScore W2103463753C2777736315 @default.
• W2103463753 hasConceptScore W2103463753C2778054964 @default.
• W2103463753 hasConceptScore W2103463753C2778466210 @default.
• W2103463753 hasConceptScore W2103463753C2778575703 @default.
• W2103463753 hasConceptScore W2103463753C2779234561 @default.
• W2103463753 hasConceptScore W2103463753C2779279991 @default.
• W2103463753 hasConceptScore W2103463753C2781087480 @default.
• W2103463753 hasConceptScore W2103463753C54355233 @default.
• W2103463753 hasConceptScore W2103463753C71315377 @default.
• W2103463753 hasConceptScore W2103463753C71924100 @default.
• W2103463753 hasConceptScore W2103463753C86803240 @default.

• next