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- W2103476879 abstract "See article by Zhong et al. [13] (pages 388–395) in this issue. The apelin receptor APJ belongs to the family of seven-transmembrane domain receptors and is coupled to inhibitory G-proteins [1,2]. Apelin is synthesized as a 77 amino acid pre-pro-peptide that can be cleaved into fragments of different sizes that activate APJ [1,2]. Apelin peptides have been shown to affect many biological functions in mammals including the neuroendocrine, cardiovascular, and immune systems [1]. It can act via autocrine, paracrine, endocrine, and exocrine signalling [1].In the cardiovascular system apelin has been shown to increase cardiac contractility when administered in pharmacological doses [3]. The implications of this effect have been discussed recently in this journal [4]. Exogenous apelin lowers arterial pressure in mice and rats [5,6]. This effect is largely due to vasodilation as a consequence of apelin-induced activation of the endothelial nitric oxide synthase (eNOS) [5]. However, in conscious sheep low doses of apelin induced no significant alterations in arterial pressure [7]. At a higher dose a clear biphasic arterial pressure response was observed consisting of initial hypotension followed by hypertension [7]. This was accompanied by reciprocal heart rate changes that were most likely baroreflex mediated [7]. These data suggest … *Tel.: +49 3834 8619300; fax: +49 3834 8618310. Email address: grisko{at}uni-greifswald.de" @default.
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- W2103476879 date "2007-06-01" @default.
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- W2103476879 title "Apelin and vascular dysfunction in type 2 diabetes" @default.
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- W2103476879 doi "https://doi.org/10.1016/j.cardiores.2007.03.026" @default.
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