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- W2103478093 abstract "Activation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link in the relationship between cytokines and depression. We aimed to develop an experimental model of chronic IDO activation based on bacille Calmette-Guérin (BCG) infection that elicits a robust increase in levels of interferon (IFN)- gamma, a key cytokine in the activation of IDO.Mice were inoculated intraperitoneally with BCG (10(7) cfu/mouse). Lung and brain IDO activity was measured over time, together with plasma levels of TRP and IFN- gamma.BCG induced, over the course of several weeks, a chronic increase in serum IFN- gamma levels that was associated with a sustained enhancement of lung and brain IDO activity and with decreases in peripheral (serum and lungs) and brain concentrations of TRP, with different time courses between tissues.The model of BCG-induced IDO activation will be useful for the study of the consequences of peripheral immune activation in the brain and the role of TRP metabolism in cytokine-induced mood alteration." @default.
- W2103478093 created "2016-06-24" @default.
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- W2103478093 date "2005-08-01" @default.
- W2103478093 modified "2023-10-07" @default.
- W2103478093 title "Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice" @default.
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- W2103478093 doi "https://doi.org/10.1086/431603" @default.
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