Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103485243> ?p ?o ?g. }
- W2103485243 endingPage "5151" @default.
- W2103485243 startingPage "5145" @default.
- W2103485243 abstract "As an important step of the active demethylation of 5-methylcytosine (5mC), human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC) from double-stranded DNA (dsDNA). Here, we present synthesis of DNA oligos containing a 2′-deoxy-2′-fluoro-d-arabinofuranosyl-5-carboxylcytidine (F-5caC) modification that act as hTDG inhibitors. The glycosylase activity assay showed that F-5caC oligos were resistant to excision by the hTDG catalytic domain (hTDGcat, residues 111–308) and they could inhibit the excision of DNA oligos containing 5caC. The electrophoretic mobility shift assay confirmed that DNA oligos containing F-5caC could bind well with unmodified hTDGcat to form a stable complex, which makes it possible to obtain the crystal structure of the complex to reveal details on how hTDGcat recognizes the DNA substrate." @default.
- W2103485243 created "2016-06-24" @default.
- W2103485243 creator A5012805315 @default.
- W2103485243 creator A5014005102 @default.
- W2103485243 creator A5030485564 @default.
- W2103485243 creator A5091114864 @default.
- W2103485243 date "2012-07-01" @default.
- W2103485243 modified "2023-10-18" @default.
- W2103485243 title "Synthesis of DNA oligos containing 2′-deoxy-2′-fluoro-d-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor" @default.
- W2103485243 cites W1845321470 @default.
- W2103485243 cites W1963834641 @default.
- W2103485243 cites W1969117816 @default.
- W2103485243 cites W1972607828 @default.
- W2103485243 cites W1980877034 @default.
- W2103485243 cites W1981463058 @default.
- W2103485243 cites W1982010715 @default.
- W2103485243 cites W1982461399 @default.
- W2103485243 cites W1982618646 @default.
- W2103485243 cites W1983987311 @default.
- W2103485243 cites W1985977968 @default.
- W2103485243 cites W1987753375 @default.
- W2103485243 cites W1988988399 @default.
- W2103485243 cites W1989457196 @default.
- W2103485243 cites W1989686694 @default.
- W2103485243 cites W1992728523 @default.
- W2103485243 cites W1996676239 @default.
- W2103485243 cites W1997453048 @default.
- W2103485243 cites W1997796525 @default.
- W2103485243 cites W2007730035 @default.
- W2103485243 cites W2011611432 @default.
- W2103485243 cites W2021775249 @default.
- W2103485243 cites W2026122224 @default.
- W2103485243 cites W2031712869 @default.
- W2103485243 cites W2034877754 @default.
- W2103485243 cites W2038449573 @default.
- W2103485243 cites W2059839436 @default.
- W2103485243 cites W2088245375 @default.
- W2103485243 cites W2088746295 @default.
- W2103485243 cites W2091841597 @default.
- W2103485243 cites W2094247278 @default.
- W2103485243 cites W2094811518 @default.
- W2103485243 cites W2102419015 @default.
- W2103485243 cites W2108664872 @default.
- W2103485243 cites W2129270269 @default.
- W2103485243 cites W2139235635 @default.
- W2103485243 cites W2143798330 @default.
- W2103485243 cites W2152451432 @default.
- W2103485243 cites W2163410022 @default.
- W2103485243 cites W2170891278 @default.
- W2103485243 cites W2171013411 @default.
- W2103485243 cites W2313074434 @default.
- W2103485243 cites W2950469006 @default.
- W2103485243 doi "https://doi.org/10.1016/j.tet.2012.04.031" @default.
- W2103485243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3375917" @default.
- W2103485243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22711938" @default.
- W2103485243 hasPublicationYear "2012" @default.
- W2103485243 type Work @default.
- W2103485243 sameAs 2103485243 @default.
- W2103485243 citedByCount "9" @default.
- W2103485243 countsByYear W21034852432016 @default.
- W2103485243 countsByYear W21034852432017 @default.
- W2103485243 countsByYear W21034852432019 @default.
- W2103485243 countsByYear W21034852432020 @default.
- W2103485243 countsByYear W21034852432022 @default.
- W2103485243 crossrefType "journal-article" @default.
- W2103485243 hasAuthorship W2103485243A5012805315 @default.
- W2103485243 hasAuthorship W2103485243A5014005102 @default.
- W2103485243 hasAuthorship W2103485243A5030485564 @default.
- W2103485243 hasAuthorship W2103485243A5091114864 @default.
- W2103485243 hasBestOaLocation W21034852432 @default.
- W2103485243 hasConcept C104317684 @default.
- W2103485243 hasConcept C129312508 @default.
- W2103485243 hasConcept C134935766 @default.
- W2103485243 hasConcept C150194340 @default.
- W2103485243 hasConcept C153911025 @default.
- W2103485243 hasConcept C185592680 @default.
- W2103485243 hasConcept C190727270 @default.
- W2103485243 hasConcept C192396546 @default.
- W2103485243 hasConcept C2775926025 @default.
- W2103485243 hasConcept C2776023528 @default.
- W2103485243 hasConcept C2776858809 @default.
- W2103485243 hasConcept C552990157 @default.
- W2103485243 hasConcept C55493867 @default.
- W2103485243 hasConcept C71240020 @default.
- W2103485243 hasConcept C86803240 @default.
- W2103485243 hasConceptScore W2103485243C104317684 @default.
- W2103485243 hasConceptScore W2103485243C129312508 @default.
- W2103485243 hasConceptScore W2103485243C134935766 @default.
- W2103485243 hasConceptScore W2103485243C150194340 @default.
- W2103485243 hasConceptScore W2103485243C153911025 @default.
- W2103485243 hasConceptScore W2103485243C185592680 @default.
- W2103485243 hasConceptScore W2103485243C190727270 @default.
- W2103485243 hasConceptScore W2103485243C192396546 @default.
- W2103485243 hasConceptScore W2103485243C2775926025 @default.
- W2103485243 hasConceptScore W2103485243C2776023528 @default.
- W2103485243 hasConceptScore W2103485243C2776858809 @default.
- W2103485243 hasConceptScore W2103485243C552990157 @default.
- W2103485243 hasConceptScore W2103485243C55493867 @default.