FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103491663> ?p ?o ?g. }

• W2103491663 endingPage "9610" @default.
• W2103491663 startingPage "9605" @default.
• W2103491663 abstract "DNA-dependent protein kinase (DNA-PK) acts through an essential relationship with DNA to participate in the regulation of multiple cellular processes. Yet the role of DNA as a cofactor in kinase activity remains to be completely elucidated. For example, although DNA-PK activity appears to be required for the resolution of hairpin coding ends in variable diversity joining recombination, kinase activity remains to be demonstrated from hairpin ends or other DNA structures. In the present study we report that DNA-PK is strongly activated from hairpin ends and structured single-stranded DNA, but that the phosphorylation of many heterologous substrates is blocked efficiently by inactivation of the kinase through autophosphorylation. However, substrates that bound efficiently to single-stranded DNA such as p53 and replication protein A were efficiently phosphorylated by DNA-PK from structured DNA. DNA-PK also was found to be active toward heterologous substrates from hairpin ends on double-stranded DNA under conditions where autophosphorylation was minimized. These results suggest that the role of DNA-PK in resolving coding end hairpins is likely to be enzymatic rather than structural, expand understanding of how DNA-PK binding to structured DNA relates to enzyme activity, and suggest a mechanism for autoregulatory control of its kinase activity in the cell." @default.
• W2103491663 created "2016-06-24" @default.
• W2103491663 creator A5021519896 @default.
• W2103491663 creator A5023259904 @default.
• W2103491663 creator A5047805997 @default.
• W2103491663 creator A5050412538 @default.
• W2103491663 creator A5069115231 @default.
• W2103491663 creator A5089497908 @default.
• W2103491663 date "2001-07-31" @default.
• W2103491663 modified "2023-09-26" @default.
• W2103491663 title "Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins" @default.
• W2103491663 cites W1499226315 @default.
• W2103491663 cites W1509547277 @default.
• W2103491663 cites W1516845708 @default.
• W2103491663 cites W1593571952 @default.
• W2103491663 cites W1805239396 @default.
• W2103491663 cites W1809586716 @default.
• W2103491663 cites W1959049775 @default.
• W2103491663 cites W1972313386 @default.
• W2103491663 cites W1977145510 @default.
• W2103491663 cites W1979303367 @default.
• W2103491663 cites W1986448084 @default.
• W2103491663 cites W1992928898 @default.
• W2103491663 cites W1999105804 @default.
• W2103491663 cites W2003196136 @default.
• W2103491663 cites W2007635472 @default.
• W2103491663 cites W2008783898 @default.
• W2103491663 cites W2016062544 @default.
• W2103491663 cites W2023579322 @default.
• W2103491663 cites W2024877615 @default.
• W2103491663 cites W2031616290 @default.
• W2103491663 cites W2035892621 @default.
• W2103491663 cites W2038875604 @default.
• W2103491663 cites W2051374545 @default.
• W2103491663 cites W2058332866 @default.
• W2103491663 cites W2059823430 @default.
• W2103491663 cites W2073469664 @default.
• W2103491663 cites W2076023322 @default.
• W2103491663 cites W2102512189 @default.
• W2103491663 cites W2103100439 @default.
• W2103491663 cites W2104979495 @default.
• W2103491663 cites W2114553575 @default.
• W2103491663 cites W2123273708 @default.
• W2103491663 cites W2127173305 @default.
• W2103491663 cites W2127414222 @default.
• W2103491663 cites W2130728712 @default.
• W2103491663 cites W2137066531 @default.
• W2103491663 cites W2159907784 @default.
• W2103491663 cites W4243706448 @default.
• W2103491663 cites W4245519065 @default.
• W2103491663 cites W4248537842 @default.
• W2103491663 doi "https://doi.org/10.1073/pnas.171211398" @default.
• W2103491663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55499" @default.
• W2103491663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11481441" @default.
• W2103491663 hasPublicationYear "2001" @default.
• W2103491663 type Work @default.
• W2103491663 sameAs 2103491663 @default.
• W2103491663 citedByCount "27" @default.
• W2103491663 countsByYear W21034916632016 @default.
• W2103491663 countsByYear W21034916632018 @default.
• W2103491663 countsByYear W21034916632020 @default.
• W2103491663 crossrefType "journal-article" @default.
• W2103491663 hasAuthorship W2103491663A5021519896 @default.
• W2103491663 hasAuthorship W2103491663A5023259904 @default.
• W2103491663 hasAuthorship W2103491663A5047805997 @default.
• W2103491663 hasAuthorship W2103491663A5050412538 @default.
• W2103491663 hasAuthorship W2103491663A5069115231 @default.
• W2103491663 hasAuthorship W2103491663A5089497908 @default.
• W2103491663 hasBestOaLocation W21034916631 @default.
• W2103491663 hasConcept C104317684 @default.
• W2103491663 hasConcept C143425029 @default.
• W2103491663 hasConcept C150109051 @default.
• W2103491663 hasConcept C153911025 @default.
• W2103491663 hasConcept C156719811 @default.
• W2103491663 hasConcept C175114707 @default.
• W2103491663 hasConcept C184235292 @default.
• W2103491663 hasConcept C31254050 @default.
• W2103491663 hasConcept C32010083 @default.
• W2103491663 hasConcept C552990157 @default.
• W2103491663 hasConcept C55493867 @default.
• W2103491663 hasConcept C67705224 @default.
• W2103491663 hasConcept C68748289 @default.
• W2103491663 hasConcept C73573662 @default.
• W2103491663 hasConcept C86339819 @default.
• W2103491663 hasConcept C86803240 @default.
• W2103491663 hasConcept C94966510 @default.
• W2103491663 hasConcept C95444343 @default.
• W2103491663 hasConcept C97029542 @default.
• W2103491663 hasConceptScore W2103491663C104317684 @default.
• W2103491663 hasConceptScore W2103491663C143425029 @default.
• W2103491663 hasConceptScore W2103491663C150109051 @default.
• W2103491663 hasConceptScore W2103491663C153911025 @default.
• W2103491663 hasConceptScore W2103491663C156719811 @default.
• W2103491663 hasConceptScore W2103491663C175114707 @default.
• W2103491663 hasConceptScore W2103491663C184235292 @default.
• W2103491663 hasConceptScore W2103491663C31254050 @default.
• W2103491663 hasConceptScore W2103491663C32010083 @default.
• W2103491663 hasConceptScore W2103491663C552990157 @default.

• next