FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103499500> ?p ?o ?g. }

• W2103499500 endingPage "599" @default.
• W2103499500 startingPage "589" @default.
• W2103499500 abstract "Consecutive exons 6A, 6B, 7 and 8 that encode the variable region of the amino-terminal domain (NTD) of the col11a1 gene product undergo a complex pattern of alternative splicing that is both tissue-dependent and developmentally regulated. Expression of col11a1 is predominantly associated with cartilage where it plays a critical role in skeletal development. At least five splice-forms (6B-7-8, 6A-7-8, 7-8, 6B-7 and 7) are found in cartilage. Splice-forms containing exon 6B or 8 have distinct distributions in the long bone during development, while in non-cartilage tissues, splice-form 6A-7-8 is typically expressed. In order to study this complex and tissue-specific alternative splicing, a mini-gene that contains mouse genomic sequence from exon 5 to 11, flanking the variable region of alpha1(XI)-NTD, was constructed. The minigene was transfected into chondrocytic (RCS) and non-chondrocytic (A204) cell lines that endogenously express alpha1(XI), as well as 293 cells which do not express alpha1(XI). Alternative splicing in RCS and A204 cells reflected the appropriate cartilage and non-cartilage patterns while 293 cells produced only 6A-7-8. This suggests that 6A-7-8 is the default splicing pathway and that cell or tissue-specific trans-acting factors are required to obtain pattern of the alternative splicing of alpha1(XI) pre-mRNA observed in chondrocytes. Deletional analysis was used to identify cis-acting regions important for regulating splicing. The presence of the intact exon 7 was required to generate the full complex chondrocytic pattern of splicing. Furthermore, deletional mapping of exon 6B identified sequences required for expression of exon 6B in RCS cells and these may correspond to purine-rich (ESE) and AC-rich (ACE) exonic splicing enhancers." @default.
• W2103499500 created "2016-06-24" @default.
• W2103499500 creator A5007618719 @default.
• W2103499500 creator A5024037872 @default.
• W2103499500 creator A5028259526 @default.
• W2103499500 creator A5052846548 @default.
• W2103499500 creator A5064831934 @default.
• W2103499500 creator A5073224610 @default.
• W2103499500 date "2001-12-01" @default.
• W2103499500 modified "2023-09-25" @default.
• W2103499500 title "Cis-acting elements regulate alternative splicing of exons 6A, 6B and 8 of the α1(XI) collagen gene and contribute to the regional diversification of collagen XI matrices" @default.
• W2103499500 cites W1505294312 @default.
• W2103499500 cites W1515000724 @default.
• W2103499500 cites W1521002902 @default.
• W2103499500 cites W1542740939 @default.
• W2103499500 cites W1548056598 @default.
• W2103499500 cites W1552327784 @default.
• W2103499500 cites W1555090655 @default.
• W2103499500 cites W1677581752 @default.
• W2103499500 cites W1795122982 @default.
• W2103499500 cites W1842953786 @default.
• W2103499500 cites W1965078322 @default.
• W2103499500 cites W1969933373 @default.
• W2103499500 cites W1970763071 @default.
• W2103499500 cites W1977126721 @default.
• W2103499500 cites W1985696544 @default.
• W2103499500 cites W1987366303 @default.
• W2103499500 cites W2004371690 @default.
• W2103499500 cites W2009764213 @default.
• W2103499500 cites W2013954472 @default.
• W2103499500 cites W2013955971 @default.
• W2103499500 cites W2016388851 @default.
• W2103499500 cites W2023081224 @default.
• W2103499500 cites W2028442510 @default.
• W2103499500 cites W2029853063 @default.
• W2103499500 cites W2030359488 @default.
• W2103499500 cites W2033701208 @default.
• W2103499500 cites W2039830387 @default.
• W2103499500 cites W2042454675 @default.
• W2103499500 cites W2045631728 @default.
• W2103499500 cites W2045984686 @default.
• W2103499500 cites W2051349620 @default.
• W2103499500 cites W2056176535 @default.
• W2103499500 cites W2057537102 @default.
• W2103499500 cites W2061926510 @default.
• W2103499500 cites W2075127121 @default.
• W2103499500 cites W2075488484 @default.
• W2103499500 cites W2077989922 @default.
• W2103499500 cites W2078744277 @default.
• W2103499500 cites W2081509786 @default.
• W2103499500 cites W2082491111 @default.
• W2103499500 cites W2094419922 @default.
• W2103499500 cites W2094434974 @default.
• W2103499500 cites W2095944775 @default.
• W2103499500 cites W2096678650 @default.
• W2103499500 cites W2104668964 @default.
• W2103499500 cites W2104887669 @default.
• W2103499500 cites W2109276727 @default.
• W2103499500 cites W2125069153 @default.
• W2103499500 cites W2132583388 @default.
• W2103499500 cites W2141186116 @default.
• W2103499500 cites W2141419420 @default.
• W2103499500 cites W2145650946 @default.
• W2103499500 cites W2146072922 @default.
• W2103499500 cites W2152182570 @default.
• W2103499500 cites W2159864549 @default.
• W2103499500 cites W2164032670 @default.
• W2103499500 doi "https://doi.org/10.1016/s0945-053x(01)00169-x" @default.
• W2103499500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11731275" @default.
• W2103499500 hasPublicationYear "2001" @default.
• W2103499500 type Work @default.
• W2103499500 sameAs 2103499500 @default.
• W2103499500 citedByCount "14" @default.
• W2103499500 countsByYear W21034995002012 @default.
• W2103499500 countsByYear W21034995002019 @default.
• W2103499500 countsByYear W21034995002022 @default.
• W2103499500 crossrefType "journal-article" @default.
• W2103499500 hasAuthorship W2103499500A5007618719 @default.
• W2103499500 hasAuthorship W2103499500A5024037872 @default.
• W2103499500 hasAuthorship W2103499500A5028259526 @default.
• W2103499500 hasAuthorship W2103499500A5052846548 @default.
• W2103499500 hasAuthorship W2103499500A5064831934 @default.
• W2103499500 hasAuthorship W2103499500A5073224610 @default.
• W2103499500 hasConcept C102063271 @default.
• W2103499500 hasConcept C104317684 @default.
• W2103499500 hasConcept C105702510 @default.
• W2103499500 hasConcept C153911025 @default.
• W2103499500 hasConcept C166342232 @default.
• W2103499500 hasConcept C194583182 @default.
• W2103499500 hasConcept C2780550940 @default.
• W2103499500 hasConcept C36823959 @default.
• W2103499500 hasConcept C42576000 @default.
• W2103499500 hasConcept C54355233 @default.
• W2103499500 hasConcept C54458228 @default.
• W2103499500 hasConcept C67705224 @default.
• W2103499500 hasConcept C86803240 @default.
• W2103499500 hasConcept C95444343 @default.
• W2103499500 hasConceptScore W2103499500C102063271 @default.

• next